LFA-1 expression in a series of colorectal adenocarcinomas

Papas, Maria G; Karatzas, Pantelis S; Papanikolaou, Ioannis S; Karamitopoulou, Evanthia; Delicha, Eumorphia M; Adler, Andreas; Triantafyllou, Konstantinos; Thomopoulou, Georgia-Heleni; Patsouris, Efstratios; Lazaris, Andreas C (2012). LFA-1 expression in a series of colorectal adenocarcinomas. Journal of gastrointestinal cancer, 43(3), pp. 462-6. New York, N.Y.: Springer 10.1007/s12029-011-9341-6

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LFA-1 is an adhesion molecule which belongs to the β2-integrin family. Overexpression of LFA-1 in hepatic natural killer cells has been associated with increased apoptosis of neoplastic cells in colorectal cancer (CRC); moreover, studies in CRC have linked LFA-1 overexpression in neoplastic cells with vascular intrusion through adhesion to endothelial cells, thus implying a possible role in creation of metastases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Karamitopoulou, Evanthia

ISSN:

1941-6628

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:32

Last Modified:

21 Jul 2014 08:24

Publisher DOI:

10.1007/s12029-011-9341-6

PubMed ID:

22083532

URI:

https://boris.unibe.ch/id/eprint/12485 (FactScience: 218834)

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