Benabdelaziz, Imane; Gómez-Ruiz, Santiago; Benkhaled, Mohammed; Carralero, Sandra; Schenker, Patricia; Salm, Andrea Alejandra; Gertsch, Jürg; Haba, Hamada (2018). New cycloartane-type ester triterpenes from Euphorbia pterococca and biological evaluation. Fitoterapia, 127, pp. 271-278. Elsevier Science 10.1016/j.fitote.2018.02.027
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From acetonic extract of the whole plant Euphorbia pterococca Brot. (Euphorbiaceae), four new cycloartane-type ester triterpenes named cycloartenyl-2'E,4'E-decadienoate (1), cycloartenyl-2'E,4'Z-decadienoate (2), 24-methylenecycloartanyl-2'E,4'Z-tetradecadienoate (3), and 24-oxo-29-norcycloartanyl-2'E,4'Z-hexadecadienoate (4) were obtained along with nine known tetracyclic triterpenes (5-13). Their structures were established mainly by extensive use of spectroscopic techniques, including 1D (H and C) and 2D homo- and heteronuclear NMR experiments (COSY, HSQC, HMBC and NOESY), and mass spectrometry (HRESIMS), and by comparison with data reported in the literature. In addition, the new compounds 1-3 have been tested for cytotoxicity, trypanocidal effects and on enzymes involved in endocannabinoid degradation. While inactive in all assays up to 100 μM, 1 showed selective inhibition of α/β-hydrolase 12 with an IC of 11.6 ± 1.9 μM.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Schenker, Patricia, Salm, Andrea Alejandra, Gertsch, Jürg |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0367-326X |
Publisher: |
Elsevier Science |
Language: |
English |
Submitter: |
Barbara Franziska Järmann-Bangerter |
Date Deposited: |
21 Feb 2019 10:57 |
Last Modified: |
05 Dec 2022 15:25 |
Publisher DOI: |
10.1016/j.fitote.2018.02.027 |
PubMed ID: |
29524564 |
Uncontrolled Keywords: |
Alpha/beta hydrolase-12 Cycloartanes Euphorbia pterococca Euphorbiaceae NMR Triterpenoids |
BORIS DOI: |
10.7892/boris.125032 |
URI: |
https://boris.unibe.ch/id/eprint/125032 |
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