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Gertsch, Jürg; Chicca, Andrea (2024). CNS Drug Discovery in Academia: Where Basic Research Meets Innovation. ChemBioChem, 25(19), e202400397. Wiley 10.1002/cbic.202400397
Kroll, Sara L; Meier, Philip; Mayo, Leah M; Gertsch, Jürg; Quednow, Boris B (2024). Endocannabinoids and related lipids linked to social exclusion in individuals with chronic non-medical prescription opioid use. Neuropsychopharmacology, 49(10), pp. 1630-1639. Springer Nature 10.1038/s41386-024-01881-8
Mistry, Hiten D; Klossner, Rahel; Scaife, Paula J; Eisele, Nicole; Kurlak, Lesia O; Kallol, Sampada; Albrecht, Christiane; Gennari-Moser, Carine; Briggs, Louise V; Broughton Pipkin, Fiona; Mohaupt, Markus G (2024). Alterations of Placental Sodium in Preeclampsia: Trophoblast Responses. Hypertension, 81(9), pp. 1924-1934. American Heart Association 10.1161/HYPERTENSIONAHA.124.23001
Hirschi, Stephan; Lemmin, Thomas; Ayoub, Nooraldeen; Kalbermatter, David; Pellegata, Daniele; Ucurum, Zöhre; Gertsch, Jürg; Fotiadis, Dimitrios (2024). Structural insights into the mechanism and dynamics of proteorhodopsin biogenesis and retinal scavenging. Nature Communications, 15(1), p. 6950. Springer Nature 10.1038/s41467-024-50960-3
Chicca, Andrea; Bátora, Daniel; Ullmer, Christoph; Caruso, Antonello; Grüner, Sabine; Fingerle, Jürgen; Hartung, Thomas; Degen, Roland; Müller, Matthias; Grether, Uwe; Pacher, Pal; Gertsch, Jürg (2024). A Highly Potent, Orally Bioavailable Pyrazole-Derived Cannabinoid CB2 Receptor- Selective Full Agonist for In Vivo Studies. ACS pharmacology & translational science, 7(8), pp. 2424-2438. ACS Publications 10.1021/acsptsci.4c00269
Kaethner, Marc; Zumstein, Pascal; Preza, Matías; Grossenbacher, Philipp; Bartetzko, Anissa; Lochner, Martin; Schürch, Stefan; Regnault, Clement; Villalobos Ramirez, Daniel; Lundström Stadelmann, Britta (27 July 2024). Investigation of the threonine metabolism of Echinococcus multilocularis: the threonine dehydrogenase as a potential drug target in alveolar echinococcosis (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2024.07.27.605433
Lazaridi, Symela; Yuan, Jing; Lemmin, Thomas (2024). Atomic insights into the signaling landscape of E. coli PhoQ histidine kinase from molecular dynamics simulations. Scientific reports, 14(1), p. 17659. Springer Nature 10.1038/s41598-024-68206-z
Bátora, Dániel; Dienes-Nagy, Ágnes; Zeng, Liming; Gerber, Christian E.; Fischer, Jérôme P.; Lochner, Martin; Gertsch, Jürg (2024). Hypersensitive quantification of major astringency markers in food and wine by substoichiometric quenching of silicon-rhodamine conjugates. Food Chemistry: X, 23, p. 101592. Elsevier 10.1016/j.fochx.2024.101592
Tomašević, Nataša; Emser, Fabiola Susanna; Muratspahić, Edin; Gattringer, Jasmin; Hasinger, Simon; Hellinger, Roland; Keov, Peter; Felkl, Manuel; Gertsch, Jürg; Becker, Christian F W; Gruber, Christian W (2024). Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor. The journal of biological chemistry, 300(6), p. 107330. American Society for Biochemistry and Molecular Biology 10.1016/j.jbc.2024.107330
Chicca, Andrea; Batora, Daniel; Ullmer, Christoph; Caruso, Antonello; Fingerle, Jürgen; Hartung, Thomas; Degen, Roland; Müller, Matthias; Grether, Uwe; Pacher, Pal; Gertsch, Jürg (29 April 2024). A highly potent, orally bioavailable pyrazole-derived cannabinoid CB2 receptor-selective full agonist for in vivo studies. (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2024.04.26.591311
Dawoody Nejad, Ladan; Annese, Tiziana; Ribatti, Domenico (2024). Lysosomal diacylglycerol pyrophosphate phosphatase is not essential in Trypanosoma brucei. Molecular biology reports, 51(578) Springer 10.1007/s11033-024-09547-w
Bátora, Daniel; Fischer, Jérôme P.; Kaderli, Reto M.; Varga, Máté; Lochner, Martin; Gertsch, Jürg (2024). Silicon-Rhodamine Functionalized Evocalcet Probes Potently and Selectively Label Calcium Sensing Receptors In Vitro, In Vivo, and Ex Vivo. ACS pharmacology & translational science, 7(5), pp. 1557-1570. ACS Publications 10.1021/acsptsci.4c00096
Schröder, Mariana; Fuenzalida, Barbara; Yi, Nan; Shahnawaz, Saira; Gertsch, Jürg; Pellegata, Daniele; Ontsouka, Edgar; Leiva, Andrea; Gutiérrez, Jaime; Müller, Martin; Brocco, Marcela A; Albrecht, Christiane (2024). LAT1-dependent placental methionine uptake is a key player in fetal programming of metabolic disease. Metabolism : clinical and experimental, 153, p. 155793. Elsevier 10.1016/j.metabol.2024.155793
Harder, Daniel; Ritzmann, Noah; Ucurum Fotiadis, Zöhre; Müller, Daniel J; Fotiadis, Dimitrios (2024). Light Color-Controlled pH-Adjustment of Aqueous Solutions Using Engineered Proteoliposomes. Advanced science, 11(15), e2307524. Wiley 10.1002/advs.202307524
Zaugg, Jonas; Lopez-Tello, Jorge; Musial, Barbara; Vaughan, Owen R; Fowden, Abigail L; Albrecht, Christiane; Sferruzzi-Perri, Amanda N (2024). Obesogenic diet in pregnancy disrupts placental iron handling and ferroptosis and stress signalling in association with fetal growth alterations. Cellular and molecular life sciences : CMLS, 81(151) Springer 10.1007/s00018-024-05192-5
Kappel, Sven; Melek, Korollus; Ross-Kaschitza, Daniela; Hauert, Barbara; Gerber, Christian E.; Lochner, Martin; Peinelt, Christine (2024). CBA (4-chloro-2-(2-chlorophenoxy)acetamido) benzoic acid) inhibits TMEM206 mediated currents and TMEM206 does not contribute to acid-induced cell death in colorectal cancer cells. Frontiers in Pharmacology, 15 Frontiers 10.3389/fphar.2024.1369513
Bátora, Dániel; Fischer, Jérôme P.; Kaderli, Reto M.; Varga, Maté; Lochner, Martin; Gertsch, Jürg (25 February 2024). Silicon-rhodamine functionalized evocalcet probes (EvoSiR) potently and selectively label calcium sensing receptors (CaSR) in vitro, in vivo and ex vivo (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2024.02.22.581561
McCafferty, Caitlyn L; Klumpe, Sven; Amaro, Rommie E; Kukulski, Wanda; Collinson, Lucy; Engel, Benjamin D (2024). Integrating cellular electron microscopy with multimodal data to explore biology across space and time. Cell, 187(3), pp. 563-584. Elsevier 10.1016/j.cell.2024.01.005
Fuenzalida, Barbara; Yañez, Maria Jose; Mueller, Martin; Mistry, Hiten D; Leiva, Andrea; Albrecht, Christiane (2024). Evidence for hypoxia-induced dysregulated cholesterol homeostasis in preeclampsia: Insights into the mechanisms from human placental cells and tissues. FASEB journal, 38(2) Federation of American Societies for Experimental Biology 10.1096/fj.202301708RR
Ekundayo, Babatunde; Arullampalam, Prakash; Gerber, Christian E.; Hämmerli, Anne-Flore; Guichard, Sabrina; Boukenna, Mey; Ross, Daniela; Lochner, Martin; Rougier, Jean-Sébastien; Stahlberg, Henning; Abriel, Hugues; Ni, Dongchun (23 January 2024). Identification of a Binding Site for Small Molecule Inhibitors Targeting Human TRPM4 (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2024.01.22.576650
Di Stefano, Miriana; Masoni, Samuele; Bononi, Giulia; Poli, Giulio; Galati, Salvatore; Gado, Francesca; Manzi, Simone; Vagaggini, Chiara; Brai, Annalaura; Caligiuri, Isabella; Asif, Kanwal; Rizzolio, Flavio; Macchia, Marco; Chicca, Andrea; Sodi, Andrea; Di Bussolo, Valeria; Minutolo, Filippo; Meier, Philip; Gertsch, Jürg; Granchi, Carlotta; ... (2024). Design, synthesis, ADME and biological evaluation of benzylpiperidine and benzylpiperazine derivatives as novel reversible monoacylglycerol lipase (MAGL) inhibitors. European journal of medicinal chemistry, 263(115916), p. 115916. Elsevier 10.1016/j.ejmech.2023.115916
Tscherrig, Dominic; Bhardwaj, Rajesh; Biner, Daniel; Dernič, Jan; Ross-Kaschitza, Daniela; Peinelt, Christine; Hediger, Matthias A; Lochner, Martin (2024). Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells. Cell calcium, 117, p. 102834. Elsevier 10.1016/j.ceca.2023.102834
Fuenzalida, Barbara; Albrecht, Christiane (2024). Assessing Cholesterol Efflux on Primary Human Trophoblast Cells. Methods in molecular biology, 2728, pp. 123-129. Springer 10.1007/978-1-0716-3495-0_10
Zaugg, Jonas; Albrecht, Christiane (2024). Assessment of Placental Sodium-Independent Leucine Uptake and Transfer in Trophoblast Cells. Methods in molecular biology, 2728, pp. 105-121. Springer 10.1007/978-1-0716-3495-0_9
Jayakumar, Remya; Dash, Manoj Kumar; Kumar, Pankaj; Sharma, Shiwakshi; Gulati, Saumya; Pandey, Akanksha; Cholke, Kaushavi; Fatima, Zeeshan; Trigun, S K; Joshi, Namrata (2024). Pharmaceutical characterization and exploration of Arkeshwara rasa in MDA-MB-231 cells. Journal of Ayurveda and integrative medicine, 15(1), p. 100823. Elsevier 10.1016/j.jaim.2023.100823
Iamshanova, Oksana; Hämmerli, Anne-Flore; Ramaye, Elise; Seljmani, Arbresh; Ross-Kaschitza, Daniela; Schärz, Noëlia; Essers, Maria; Guichard, Sabrina; Rougier, Jean-Sébastien; Abriel, Hugues (2024). The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5. PLoS ONE, 19(3) Public Library of Science 10.1371/journal.pone.0298820
Rodella, Chiara; Lazaridi, Symela; Lemmin, Thomas (2024). TemBERTure: advancing protein thermostability prediction with deep learning and attention mechanisms. Bioinformatics advances, 4(1) Oxford University Press 10.1093/bioadv/vbae103
Liu, Yangci; Zhai, Haoming; Alemayehu, Helen; Boulanger, Jérôme; Hopkins, Lee J; Borgeaud, Alicia C; Heroven, Christina; Howe, Jonathan D; Leigh, Kendra E; Bryant, Clare E; Modis, Yorgo (2023). Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization. Nature communications, 14(1), p. 7246. Nature Publishing Group 10.1038/s41467-023-43180-8
Reiners, Johanna Christina; Leopold, Laura; Hallebach, Vera; Sinske, Daniela; Meier, Philip; Amoroso, Mattia; Langgartner, Dominik; Reber, Stefan O; Knöll, Bernd (2023). Acute stress modulates the outcome of traumatic brain injury-associated gene expression and behavioral responses. FASEB journal, 37(11), e23218. Federation of American Societies for Experimental Biology 10.1096/fj.202301035R
Wang, Lei; Bütikofer, Peter (2023). Lactose Permease Scrambles Phospholipids. Biology, 12(11) MDPI 10.3390/biology12111367
Jiang, Shan; Steup, Lydia C; Kippnich, Charlotte; Lazaridi, Symela; Malengo, Gabriele; Lemmin, Thomas; Yuan, Jing (2023). The inhibitory mechanism of a small protein reveals its role in antimicrobial peptide sensing. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 120(41), e2309607120. National Academy of Sciences 10.1073/pnas.2309607120
Papapostolou, Irida; Bochen, Florian; Peinelt, Christine; Maldifassi, Maria Constanza (2023). A Simple and Fast Method for the Formation and Downstream Processing of Cancer-Cell-Derived 3D Spheroids: An Example Using Nicotine-Treated A549 Lung Cancer 3D Spheres. Methods and protocols, 6(5) MDPI AG 10.3390/mps6050094
Alexander, Stephen P H; Fabbro, Doriano; Kelly, Eamonn; Mathie, Alistair A; Peters, John A; Veale, Emma L; Armstrong, Jane F; Faccenda, Elena; Harding, Simon D; Davies, Jamie A; Annett, Stephanie; Boison, Detlev; Burns, Kathryn Elisa; Dessauer, Carmen; Gertsch, Jurg; Helsby, Nuala Ann; Izzo, Angelo A; Ostrom, Rennolds; Papapetropoulos, Andreas; Pyne, Nigel J; ... (2023). The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. British journal of pharmacology, 180 Suppl 2, S289-S373. Wiley-Blackwell 10.1111/bph.16181
Maccarrone, Mauro; Di Marzo, Vincenzo; Gertsch, Juerg; Grether, Uwe; Howlett, Allyn C; Hua, Tian; Makriyannis, Alexandros; Piomelli, Daniele; Ueda, Natsuo; van der Stelt, Mario (2023). Goods and bads of endocannabinoid system as a therapeutic target: Lessons learned after 30 years. Pharmacological reviews, 75(5), pp. 885-958. American Society for Pharmacology and Experimental Therapeutics 10.1124/pharmrev.122.000600
Krishnan, Sandhya R; Skiba, Adrianna; Luca, Simon Vlad; Marcourt, Laurence; Wolfender, Jean-Luc; Skalicka-Woźniak, Krystyna; Gertsch, Jürg (2023). Bioactivity-guided isolation of trypanocidal coumarins and dihydro-pyranochromones from selected Apiaceae plant species. Phytochemistry, 213, p. 113770. Elsevier 10.1016/j.phytochem.2023.113770
Gertsch, Jürg; Heilmann, Jörg; Skaltsa, Eleni (2023). Editorial. Phytochemistry, 213(113781), p. 113781. Elsevier 10.1016/j.phytochem.2023.113781
Selimi, Zoja; Rougier, Jean-Sébastien; Abriel, Hugues; Kucera, Jan P (2023). A detailed analysis of single-channel Nav 1.5 recordings does not reveal any cooperative gating. The journal of physiology, 601(17), pp. 3847-3868. The Physiological Society 10.1113/JP284861
Thompson, Danielle; Cismaru, Christiana Victoria; Rougier, Jean-Sébastien; Schwemmle, Martin; Zimmer, Gert (2023). The M2 proteins of bat influenza A viruses reveal atypical features compared to conventional M2 proteins. Journal of virology, 97(8), e0038823. American Society for Microbiology 10.1128/jvi.00388-23
Fischer, Jérôme Paul; Bátora, Dániel; Dick, Luca Julian; Kaderli, Reto Martin; Gertsch, Jürg; Lochner, Martin (8 August 2023). Developing Molecular Tools for the Study and Detection of Calcium-Sensing Receptor [MC-112]. CHIMIA, 77(7/8), p. 526. Schweizerische Chemische Gesellschaft
Gerber, Christian Elias; Grossenbacher, Philipp; Singer, Simon Alex; Lochner, Martin (8 August 2023). Development of novel 4-chloro-2-(2-phenoxyacetamido)benzoic acid-based TRPM4 inhibitors [MC-115]. CHIMIA, 77(7/8), p. 526. Schweizerische Chemische Gesellschaft
Papapostolou, Irida; Ross, Daniela; Bochen, Florian; Peinelt, Christine; Maldifassi, Maria Constanza (2023). Contribution of the α5 nAChR Subunit and α5SNP to Nicotine-Induced Proliferation and Migration of Human Cancer Cells. Cells, 12(15) MDPI 10.3390/cells12152000
Khaddaj, Rasha; Kukulski, Wanda (2023). Piecing together the structural organisation of lipid exchange at membrane contact sites. Current opinion in cell biology, 83, p. 102212. Elsevier 10.1016/j.ceb.2023.102212
Arullampalam, Prakash; Essers, Maria C; Boukenna, Mey; Guichard, Sabrina; Rougier, Jean-Sébastien; Abriel, Hugues (2023). Knockdown of the TRPM4 channel alters cardiac electrophysiology and hemodynamics in a sex- and age-dependent manner in mice. Physiological reports, 11(16), e15783. The American Physiological Society 10.14814/phy2.15783
Iamshanova, Oksana; Rougier, Jean-Sébastien; Abriel, Hugues (2023). Exploring the Oligomerization of Nav1.5 and Its Implication for the Dominant-Negative Effect. Bioelectricity, 5(4), pp. 279-289. Mary Ann Liebert 10.1089/bioe.2023.0014
Skiba, Adrianna; Pellegata, Daniele; Morozova, Veronika; Kozioł, Ewelina; Budzyńska, Barbara; Lee, Simon Ming-Yuen; Gertsch, Jürg; Skalicka-Woźniak, Krystyna (2023). Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation. Cells, 12(11) MDPI 10.3390/cells12111540
Maldifassi, Maria Constanza; Campello, Hugo Rego; Gallagher, Timothy; Lester, Henry A; Dougherty, Dennis A (2023). Human α6β4 nicotinic acetylcholine receptor: heterologous expression and agonist behavior provide insights into the immediate binding site. Molecular pharmacology, 103(6), pp. 339-347. American Society for Pharmacology and Experimental Therapeutics 10.1124/molpharm.123.000672
Wozny, Michael R; Di Luca, Andrea; Morado, Dustin R; Picco, Andrea; Khaddaj, Rasha; Campomanes, Pablo; Ivanović, Lazar; Hoffmann, Patrick C; Miller, Elizabeth A; Vanni, Stefano; Kukulski, Wanda (2023). In situ architecture of the ER-mitochondria encounter structure. Nature, 618(7963), pp. 188-192. Macmillan Journals Ltd. 10.1038/s41586-023-06050-3
Ontsouka, Edgar; Schroeder, Mariana; Ok, Linda; Vaillancourt, Cathy; Stroka, Deborah; Albrecht, Christiane (2023). The Placenta-A New Source of Bile Acids during Healthy Pregnancy? First Results of a Gene Expression Study in Humans and Mice. International journal of molecular sciences, 24(11) MDPI 10.3390/ijms24119511
Kara, Nilufer; Ayoub, Nooraldeen; Ilgu, Huseyin; Fotiadis, Dimitrios; Ilgu, Muslum (2023). Aptamers Targeting Membrane Proteins for Sensor and Diagnostic Applications. Molecules, 28(9) MDPI 10.3390/molecules28093728
Boukenna, Mey; Rougier, Jean-Sébastien; Aghagolzadeh, Parisa; Pradervand, Sylvain; Guichard, Sabrina; Hämmerli, Anne-Flore; Pedrazzini, Thierry; Abriel, Hugues (2023). Multiomics uncover the pro-inflammatory role of Trpm4 deletion after myocardial infarction in mice. American journal of physiology - heart and circulatory physiology, 324(4), H504-H518. American Physiological Society 10.1152/ajpheart.00671.2022
Ayoub, Nooraldeen; Roth, Patrick; Ucurum, Zöhre; Fotiadis, Dimitrios; Hirschi, Stephan (2023). Structural and biochemical insights into His-tag-induced higher-order oligomerization of membrane proteins by cryo-EM and size exclusion chromatography. Journal of structural biology, 215(1), p. 107924. Elsevier 10.1016/j.jsb.2022.107924
Ganeva, Iva; Lim, Koini; Boulanger, Jerome; Hoffmann, Patrick C; Muriel, Olivia; Borgeaud, Alicia C; Hagen, Wim J H; Savage, David B; Kukulski, Wanda (2023). The architecture of Cidec-mediated interfaces between lipid droplets. Cell reports, 42(2), p. 112107. Cell Press 10.1016/j.celrep.2023.112107
Selimi, Zoja; Rougier, Jean-Sébastien; Abriel, Hugues; Kucera, Jan P (2023). No evidence of functional interactions between cardiac sodium channels. Biophysical journal, 122(3 S1), 101a-102a. Elsevier 10.1016/j.bpj.2022.11.736
Kalbermatter, David; Jeckelmann, Jean-Marc; Wyss, Marianne; Shrestha, Neeta; Pliatsika, Dimanthi; Riedl, Rainer; Lemmin, Thomas; Plattet, Philippe; Fotiadis, Dimitrios (2023). Structure and supramolecular organization of the canine distemper virus attachment glycoprotein. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 120(6), e2208866120. National Academy of Sciences NAS 10.1073/pnas.2208866120
Kolatt Chandran, Sailendrakumar; Yiannakas, Adonis; Kayyal, Haneen; Salalha, Randa; Cruciani, Federica; Mizrahi, Liron; Khamaisy, Mohammad; Stern, Shani; Rosenblum, Kobi (2023). Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons correlates with the confidence of taste valence encoding. eNeuro, 10(1) Society for Neuroscience 10.1523/ENEURO.0302-22.2022
Reynoso-Moreno, Ines; Rau, Mark; Chicca, Andrea; Nicolussi, Simon; Gertsch, Jürg (2023). Assay of Endocannabinoid Uptake. Methods in molecular biology, 2576, pp. 329-348. Springer 10.1007/978-1-0716-2728-0_28
Kantipudi, Satish; Harder, Daniel; Fotiadis, Dimitrios (2023). Characterization of substrates and inhibitors of the human heterodimeric transporter 4F2hc-LAT1 using purified protein and the scintillation proximity radioligand binding assay. Frontiers in physiology, 14(1148055), p. 1148055. Frontiers Research Foundation 10.3389/fphys.2023.1148055
Ontsouka, Edgar; Schröder, Mariana; Albrecht, Christiane (2023). Revisited role of the placenta in bile acid homeostasis. Frontiers in physiology, 14(1213757), p. 1213757. Frontiers Research Foundation 10.3389/fphys.2023.1213757
EL Makhzen, Nada; Daimi, Houria; Bouguenouch, Laila; Abriel, Hugues (2023). The burden of cystic fibrosis in North Africa. Frontiers in genetics, 14 Frontiers Media SA 10.3389/fgene.2023.1295008
Preti, Barbara; Rougier, Jean-Sébastien; Papapostolou, Irida; Bochen, Florian; Gerber, Christian E; Abriel, Hugues; Lochner, Martin; Peinelt, Christine (2022). Targeting Ion Channel TRPM4. CHIMIA, 76(12), pp. 1039-1044. Schweizerische Chemische Gesellschaft 10.2533/chimia.2022.1039
Zaugg, Jonas; Pujol Giménez, Jonai; Cabra, Romina Silvia; Hofstetter, Wilhelm; Hediger, Matthias; Albrecht, Christiane (2022). New Insights into the Physiology of Iron Transport: An Interdisciplinary Approach. CHIMIA, 76(12), pp. 996-1004. 10.2533/chimia.2022.996
Jeckelmann, Jean-Marc; Zaugg, Jonas; Morozova, Veronika; Müller, Jennifer; Kantipudi, Satish; Schröder, Mariana; Graff, Julien; Albrecht, Christiane; Altmann, Karl-Heinz; Gertsch, Jürg; Fotiadis, Dimitrios (2022). Structure, Function and Pharmacology of SLC7 Family Members and Homologues. CHIMIA, 76(12), pp. 1011-1018. Schweizerische Chemische Gesellschaft 10.2533/chimia.2022.1011
Rossetti, Valentina; Abriel, Hugues (2022). The NCCR TransCure: An Incubator for Interdisciplinary Research. CHIMIA, 76(12), pp. 992-995. Schweizerische Chemische Gesellschaft 10.2533/chimia.2022.992
Abriel, Hugues; Reymond, Jean-Louis (2022). NCCR TransCure - Excellence in Membrane Transport Research from 2010 until 2022. CHIMIA, 76(12), p. 989. Schweizerische Chemische Gesellschaft
Hill, Emily; Huang, Xianglin; Del Popolo, Ivana; La Mache, Circe; Lochner, Martin; Ladds, Graham; Frenguelli, Bruno G.; Wall, Mark J. (2 December 2022). Species-dependent actions of the Goαb selective adenosine A1 receptor agonist BnOCPA (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2022.12.02.518704
Preti, Barbara; Suchankova, Anna; Deganutti, Giuseppe; Leuenberger, Michele; Barkan, Kerry; Manulak, Iga; Huang, Xianglin; Carvalho, Sabrina; Ladds, Graham; Lochner, Martin (2022). Discovery and Structure-Activity Relationship Studies of Novel Adenosine A1 Receptor-Selective Agonists. Journal of medicinal chemistry, 65(21), pp. 14864-14890. American Chemical Society 10.1021/acs.jmedchem.2c01414
Hirschi, Stephan; Ward, Thomas R; Meier, Wolfgang P; Müller, Daniel J; Fotiadis, Dimitrios (2022). Synthetic Biology: Bottom-Up Assembly of Molecular Systems. Chemical reviews, 122(21), pp. 16294-16328. American Chemical Society 10.1021/acs.chemrev.2c00339
Melero, Alejandro; Boulanger, Jerome; Kukulski, Wanda; Miller, Elizabeth A (2022). Ultrastructure of COPII vesicle formation in yeast characterised by correlative light and electron microscopy. Molecular biology of the cell, 33(13), ar122. American Society for Cell Biology 10.1091/mbc.E22-03-0103
Jeckelmann, Jean-Marc; Lemmin, Thomas; Schlapschy, Martin; Skerra, Arne; Fotiadis, Dimitrios (2022). Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM. Scientific reports, 12(1), p. 18269. Springer Nature 10.1038/s41598-022-23270-1
Grossenbacher, Philipp; Essers, Maria C; Moser, Joël; Singer, Simon A; Häusler, Stephanie; Stieger, Bruno; Rougier, Jean-Sébastien; Lochner, Martin (2022). Bioorthogonal site-selective conjugation of fluorescent dyes to antibodies: method and potential applications. RSC advances, 12(44), pp. 28306-28317. Royal Society of Chemistry 10.1039/d2ra05580e
Abou Hamdan, Abbas; Mahler, Roman; Grossenbacher, Philipp; Biner, Olivier; Sjöstrand, Dan; Lochner, Martin; Högbom, Martin; von Ballmoos, Christoph (2022). Functional design of bacterial superoxide:quinone oxidoreductase. Biochimica et biophysica acta. Bioenergetics, 1863(7), p. 148583. Elsevier 10.1016/j.bbabio.2022.148583
Kappel, Sven; Peinelt, Christine (2022). Targeting CRAC channels in inflammatory bowel disease. EMBO molecular medicine, 14(9), e16489. EMBO Press 10.15252/emmm.202216489
Graff, Julien; Müller, Jennifer; Sadurní, Anna; Rubin, Matthias; Cuissa, Inês André Canivete; Keller, Claudia; Hartmann, Marco; Singer, Simon; Gertsch, Jürg; Altmann, Karl-Heinz (2022). The Evaluation of L-Tryptophan Derivatives as Inhibitors of the LType Amino Acid Transporter LAT1 (SLC7A5). ChemMedChem, 17(17), e202200308. Wiley-VCH 10.1002/cmdc.202200308
Ruggeri, Francesca; Schwemmer, Christian; Stauffer, Mirko; Nicollier, Philippe; Figueiredo da Silva, Jacqueline; Bosshart, Patrick D; Kochems, Kirstin; Fotiadis, Dimitrios; Knoll, Armin; Wolf, Heiko (2022). Placement of Biological Membrane Patches in a Nanofluidic Gap With Control Over Position and Orientation. Advanced materials interfaces, 9(23), p. 2200941. Wiley 10.1002/admi.202200941
Vachalova, Veronika; Karahoda, Rona; Ottaviani, Martina; Anandam, Kasin Yadunandam; Abad, Cilia; Albrecht, Christiane; Staud, Frantisek (2022). Functional reorganization of monoamine transport systems during villous trophoblast differentiation: evidence of distinct differences between primary human trophoblasts and BeWo cells. Reproductive biology and endocrinology, 20(1), p. 112. BioMed Central 10.1186/s12958-022-00981-8
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Horváth, Béla; Mukhopadhyay, Partha; Kechrid, Malek; Patel, Vivek; Tanchian, Galin; Wink, David A; Gertsch, Jürg; Pacher, Pál (2012). β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free radical biology & medicine, 52(8), pp. 1325-33. San Diego, Calif.: Elsevier 10.1016/j.freeradbiomed.2012.01.014
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Kovacs, Gergely; Danko, Tamas; Bergeron, Marc J; Balazs, Bernadett; Suzuki, Yoshiro; Zsembery, Akos; Hediger, Matthias A (2011). Heavy metal cations permeate the TRPV6 epithelial cation channel. Cell calcium, 49(1), pp. 43-55. Amsterdam: Elsevier 10.1016/j.ceca.2010.11.007
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Jeckelmann, Jean-Marc; Harder, Daniel; Mari, Stefania A; Meury, Marcel; Ucurum, Zöhre; Müller, Daniel J; Erni, Bernhard; Fotiadis, Dimitrios (2011). Structure and function of the glucose PTS transporter from Escherichia coli. Journal of structural biology, 176(3), pp. 395-403. San Diego, Calif.: Elsevier 10.1016/j.jsb.2011.09.012
Bergeron, Marc J.; Boggavarapu, Rajendra; Meury, Marcel; Ucurum, Zöhre; Caron, Luc; Isenring, Paul; Hediger, Matthias A.; Fotiadis, Dimitrios (2011). Frog oocytes to unveil the structure and supramolecular organization of human transport proteins. PLoS ONE, 6(7), e21901. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0021901
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Jeckelmann, Jean-Marc; Palacin, Manuel; Fotiadis, Dimitrios (2011). A tool for the qualitative comparison of membrane-embedded and detergent-solubilized membrane protein structures in projection. Journal of structural biology, 173(2), pp. 375-81. San Diego, Calif.: Elsevier 10.1016/j.jsb.2010.09.005
Ilgü, Hüseyin; Turan, Taylan; Şanli-Mohameda, Gülşa (2011). Immobilization and characterization of recombinant esterase enzyme on chitosan nanoparticles. Journal of macromolecular science. Part A - pure and applied chemistry, 48(9), pp. 713-721. Taylor & Francis 10.1080/10601325.2011.596050
Palanivelu, Dinesh V; Goepfert, Arnaud; Meury, Marcel; Guye, Patrick; Dehio, Christoph; Schirmer, Tilman (2011). Fic domain-catalyzed adenylylation: insight provided by the structural analysis of the type IV secretion system effector BepA. Protein science, 20(3), pp. 492-9. Malden, Mass.: Wiley-Blackwell 10.1002/pro.581
Sigel, Erwin; Baur, Roland; Rácz, Ildiko; Marazzi, Janine; Smart, Trevor G; Zimmer, Andreas; Gertsch, Jürg (2011). The major central endocannabinoid directly acts at GABA(A) receptors. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 108(44), pp. 18150-5. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.1113444108
Marazzi, Janine; Kleyer, Jonas; Paredes, Juan Manuel Viveros; Gertsch, Jürg (2011). Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. Journal of immunological methods, 373(1-2), pp. 219-28. Amsterdam: Elsevier 10.1016/j.jim.2011.08.021
Nievergelt, Andreas; Marazzi, Janine; Schoop, Roland; Altmann, Karl-Heinz; Gertsch, Jürg (2011). Ginger phenylpropanoids inhibit IL-1beta and prostanoid secretion and disrupt arachidonate-phospholipid remodeling by targeting phospholipases A2. Journal of immunology, 187(8), pp. 4140-50. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.1100880
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Ritchie, M R; Gertsch, J; Klein, P; Schoop, R (2011). Effects of Echinaforce® treatment on ex vivo-stimulated blood cells. Phytomedicine, 18(10), pp. 826-31. Amsterdam: Elsevier 10.1016/j.phymed.2011.05.011
Maffei, Massimo E; Gertsch, Jürg; Appendino, Giovanni (2011). Plant volatiles: production, function and pharmacology. Natural product reports, 28(8), pp. 1359-80. Cambridge: Royal Society of Chemistry 10.1039/c1np00021g
Gertsch, Jürg (2011). Natural products in chemical biology. Current drug targets, 12(11), pp. 1513-4. Hilversum: Bentham Science Publishers 10.2174/138945011798109518
Ramesha, B T; Gertsch, Jürg; Ravikanth, G; Priti, V; Ganeshaiah, K N; Uma Shaanker, R (2011). Biodiversity and chemodiversity: future perspectives in bioprospecting. Current drug targets, 12(11), pp. 1515-30. Hilversum: Bentham Science Publishers
Zhang, Yuxun; Xie, Zhaojun; Wang, Lirong; Schreiter, Brielle; Lazo, John S; Gertsch, Jurg; Xie, Xiang-Qun (2011). Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor. International immunopharmacology, 11(9), pp. 1303-10. Amsterdam: Elsevier 10.1016/j.intimp.2011.04.013
Gertsch, Jürg (2011). Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. Planta medica, 77(11), pp. 1086-98. Stuttgart: Thieme 10.1055/s-0030-1270904
Schiess, Raphael; Gertsch, Jürg; Schweizer, W Bernd; Altmann, Karl-Heinz (2011). Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants. Organic letters, 13(6), pp. 1436-9. Washington, D.C.: American Chemical Society 10.1021/ol200114k
Bergeron, Marc J; Bürzle, Marc; Kovacs, Gergely; Simonin, Alexandre; Hediger, Matthias A (2011). Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B. Journal of biological chemistry, 286(13), pp. 11242-53. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M110.171728
Sigel, Erwin; Lüscher, Benjamin P (2011). A closer look at the high affinity benzodiazepine binding site on GABAA receptors. Current topics in medicinal chemistry, 11(2), pp. 241-6. Hilversum: Bentham Science Publishers 10.2174/156802611794863562
Lis, Annette; Zierler, Susanna; Peinelt, Christine; Fleig, Andrea; Penner, Reinhold (2010). A single lysine in the N-terminal region of store-operated channels is critical for STIM1-mediated gating. Journal of general physiology, 136(6), pp. 673-686. Rockefeller University Press 10.1085/jgp.201010484
Bogeski, Ivan; Al-Ansary, Dalia; Qu, Bin; Niemeyer, Barbara A; Hoth, Markus; Peinelt, Christine (2010). Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert review of clinical pharmacology, 3(3), pp. 291-303. Taylor & Francis 10.1586/ecp.10.23
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Ambort, Daniel; Brellier, Florence; Becker-Pauly, Christoph; Stöcker, Walter; Andrejevic-Blant, Snezana; Chiquet, Matthias; Sterchi, Erwin E (2010). Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading. Matrix biology, 29(1), pp. 31-42. Amsterdam: Elsevier 10.1016/j.matbio.2009.08.007
Hofstetter, Willy; Siegrist, Mark; Simonin, Alexandre; Bonny, Olivier; Fuster, Daniel G (2010). Sodium/hydrogen exchanger NHA2 in osteoclasts: subcellular localization and role in vitro and in vivo. Bone, 47(2), pp. 331-340. New York, N.Y.: Elsevier 10.1016/j.bone.2010.04.605
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Simonin, Alexandre; Fuster, Daniel Guido (2010). Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function. Journal of biological chemistry, 285(49), pp. 38293-38303. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M110.115089
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Altmann, Michael; Linder, Patrick (2010). Power of yeast for analysis of eukaryotic translation initiation. Journal of biological chemistry, 285(42), pp. 31907-12. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.R110.144196
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Bütikofer, Peter; Greganova, Eva; Liu, Yuk-Chien; Edwards, Ian J; Lehane, Michael J; Acosta-Serrano, Alvaro (2010). Lipid remodelling of glycosylphosphatidylinositol (GPI) glycoconjugates in procyclic-form trypanosomes: biosynthesis and processing of GPIs revisited. Biochemical journal, 428(3), pp. 409-18. London: Portland Press 10.1042/BJ20100229
Greganova, E; Buetikofer, P; Acosta Serrano, A (2010). The lipid portion of protease resistant surface glycoconjugate from Trypanosoma congolense is composed of triacylated phosphatidylinositol lipids and contains myristate. Molecular and biochemical parasitology, 2010(171), pp. 50-54. Amsterdam: Elsevier
Kronenberg, Daniel; Bruns, Bernd C; Moali, Catherine; Vadon-Le Goff, Sandrine; Sterchi, Erwin E; Traupe, Heiko; Böhm, Markus; Hulmes, David J S; Stöcker, Walter; Becker-Pauly, Christoph (2010). Processing of procollagen III by meprins: new players in extracellular matrix assembly? Journal of Investigative Dermatology, 130(12), pp. 2727-35. New York, N.Y.: Nature Publishing 10.1038/jid.2010.202
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Luethi, Erika; Nguyen, Kong T; Bürzle, Marc; Blum, Lorenz C; Suzuki, Yoshiro; Hediger, Matthias; Reymond, Jean-Louis (2010). Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB). Journal of medicinal chemistry, 53(19), pp. 7236-50. Easton, Pa.: American Chemical Society 10.1021/jm100959g
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Baur, Roland; Lüscher, Benjamin P; Richter, Lars; Sigel, Erwin (2010). A residue close to ?1 loop F disrupts modulation of GABAA receptors by benzodiazepines while their binding is maintained. Journal of neurochemistry, 115(6), pp. 1478-85. Oxford: Wiley-Blackwell 10.1111/j.1471-4159.2010.07052.x
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Sigel, E (2010). Microinjection into Xenopus oocytes. In: Encyclopedia of Life Sciences. Chichester: John Wiley & Sons Ltd 10.1002/9780470015902.a0002658.pub2
Dietrich, Silvia Anthoine; Riediker, Linda; Gertsch, Jürg; Altmann, Karl-Heinz (2010). Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting. CHIMIA, 64(3), pp. 136-9. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2010.136
Altmann, Karl-Heinz; Cachoux, Frédéric; Feyen, Fabian; Gertsch, Jürg; Kuzniewski, Christian N; Wartmann, Markus (2010). Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold. CHIMIA, 64(1-2), pp. 8-13. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2010.8
Gertsch, Jürg; Pertwee, Roger G; Di Marzo, Vincenzo (2010). Phytocannabinoids beyond the Cannabis plant - do they exist? British journal of pharmacology, 160(3), pp. 523-9. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2010.00745.x
De Simone, Filippo; Gertsch, Jürg; Waser, Jérôme (2010). Catalytic selective cyclizations of aminocyclopropanes: formal synthesis of aspidospermidine and total synthesis of goniomitine. Angewandte Chemie (International ed.), 49(33), pp. 5767-70. Weinheim: Wiley-VCH 10.1002/anie.201001853
Leonti, Marco; Casu, Laura; Solinas, Maria Novella; Cottiglia, Filippo; Caboni, Pierluigi; Floris, Costantino; Gertsch, Juerg; Saba, Anna Rita (2010). A chromone from Seseli praecox (Apiaceae). Natural product communications, 5(4), pp. 551-4. Westerville, Ohio: Natural Product Communications NPC
Erdélyi, Máté; Navarro-Vázquez, Armando; Pfeiffer, Bernhard; Kuzniewski, Christian N; Felser, Andrea; Widmer, Toni; Gertsch, Jürg; Pera, Benet; Díaz, José Fernando; Altmann, Karl-Heinz; Carlomagno, Teresa (2010). The binding mode of side chain- and C3-modified epothilones to tubulin. ChemMedChem, 5(6), pp. 911-920. Weinheim: Wiley-VCH 10.1002/cmdc.201000050
Zurwerra, Didier; Gertsch, Jürg; Altmann, Karl-Heinz (2010). Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin. Organic letters, 12(10), pp. 2302-5. Washington, D.C.: American Chemical Society 10.1021/ol100665m
Nievergelt, Andreas; Huonker, Peter; Schoop, Roland; Altmann, Karl-Heinz; Gertsch, Jürg (2010). Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorganic & medicinal chemistry, 18(9), pp. 3345-51. Amsterdam: Elsevier 10.1016/j.bmc.2010.02.062
Leonti, Marco; Casu, Laura; Gertsch, Jürg; Bonsignore, Leonardo; Floris, Costantino; Casu, Mariano; Cottiglia, Filippo (2010). A pterocarpan from the seeds of Bituminaria morisiana. Journal of natural medicines, 64(3), pp. 354-7. Tōkyō: Springer 10.1007/s11418-010-0408-7
Shwe, Htay Htay; Aye, Mye; Sein, Myint Myint; Htay, Khin Than; Kreitmeier, Peter; Gertsch, Jürg; Reiser, Oliver; Heilmann, Jörg (2010). Cytotoxic steroidal saponins from the rhizomes of Tacca integrifolia. Chemistry & Biodiversity, 7(3), pp. 610-22. Zürich: Verlag Helvetica Chimica Acta
Leonti, Marco; Casu, Laura; Raduner, Stefan; Cottiglia, Filippo; Floris, Costantino; Altmann, Karl-Heinz; Gertsch, Jürg (2010). Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochemical pharmacology, 79(12), pp. 1815-26. New York, N.Y.: Elsevier 10.1016/j.bcp.2010.02.015
Wullschleger, Christoph W; Gertsch, Jürg; Altmann, Karl-Heinz (2010). Stereoselective synthesis of a monocyclic peloruside a analogue. Organic letters, 12(5), pp. 1120-3. Washington, D.C.: American Chemical Society 10.1021/ol100123p
Peng, Jiangnan; Kudrimoti, Sucheta; Prasanna, Sivaprakasam; Odde, Srinivas; Doerksen, Robert J; Pennaka, Hari K; Choo, Yeun-Mun; Rao, Karumanchi V; Tekwani, Babu L; Madgula, Vamsi; Khan, Shabana I; Wang, Bin; Mayer, Alejandro M S; Jacob, Melissa R; Tu, Lan Chun; Gertsch, Jürg; Hamann, Mark T (2010). Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Journal of medicinal chemistry, 53(1), pp. 61-76. Easton, Pa.: American Chemical Society
Greganova, E; Heller, M; Bütikofer, P (2010). A structural domain mediates attachment of ethanolamine phosphoglycerol to eukaryotic elongation factor 1A in Trypanosoma brucei. PLoS ONE, 5(3), e9486. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0009486
Kempna, Petra; Ricciarelli, Roberta; Azzi, Angelo; Zingg, Jean-Marc (2010). Alternative splicing and gene polymorphism of the human TAP3/SEC14L4 gene. Molecular biology reports, 37(7), pp. 3503-3508. Springer 10.1007/s11033-009-9943-2
Peinelt, Christine; Beck, Andreas; Monteilh-Zoller, Mahealani K; Penner, Reinhold; Fleig, Andrea (2009). IP(3) receptor subtype-dependent activation of store-operated calcium entry through I(CRAC). Cell calcium, 45(4), pp. 326-330. Elsevier 10.1016/j.ceca.2008.12.001
Wiedemann, S; Lutz, B; Albrecht, C; Kuehn, R; Killermann, B; Einspanier, R; Meyer, H.H.D. (2009). Fate of genetically modified maize and conventional rapeseed, and endozoochory in wild boar (Sus scrofa). Mammalian biology, 3(74), pp. 191-197. München: Elsevier 10.1016/j.mambio.2008.07.002
Shedova, E; Albrecht, C; Zverlov, V.V.; Schwarz, W.H. (2009). Stimulation of bacterial DNA transformation by cattle saliva: implications for using genetically modified plants in animal feed. World journal of microbiology & biotechnology, 3(25), 457-463 [7 page(s) (article)] (3/4 p.). Oxford: Springer 10.1007/s11274-008-9910-4
Gertsch, Jürg; Meier, Sarah; Müller, Martin; Altmann, Karl-Heinz (2009). Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide. ChemBioChem, 10(1), pp. 166-75. Weinheim: Wiley-VCH 10.1002/cbic.200800556
Banerjee, S; Oneda, B; Yap, L M; Jewell, D P; Matters, G L; Fitzpatrick, L R; Seibold, F; Sterchi, E E; Ahmad, T; Lottaz, D; Bond, J S (2009). MEP1A allele for meprin A metalloprotease is a susceptibility gene for inflammatory bowel disease. Mucosal immunology, 2(3), pp. 220-31. New York, N.Y.: Nature Publishing Group 10.1038/mi.2009.3
Signorell, Aita; Gluenz, Eva; Rettig, Jochen; Schneider, André; Shaw, Michael; Gull, Keith; Bütikofer, Peter (2009). Perturbation of phosphatidylethanolamine synthesis affects mitochondrial morphology and cell-cycle progression in procyclic-form Trypanosoma brucei. Molecular microbiology, 72(4), pp. 1068-79. Oxford: Blackwell Science 10.1111/j.1365-2958.2009.06713.x
Vassella, Erik; Oberle, Michael; Urwyler, Simon; Renggli, Christina Kunz; Studer, Erwin; Hemphill, Andrew; Fragoso, Cristina; Bütikofer, Peter; Brun, Reto; Roditi, Isabel (2009). Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS ONE, 4(2), e4493. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0004493
Passarella, Daniele; Comi, Daniela; Cappelletti, Graziella; Cartelli, Daniele; Gertsch, Juerg; Quesada, Ana R; Borlak, Jurgen; Altmann, Karl-Heinz (2009). Synthesis and biological evaluation of epothilone A dimeric compounds. Bioorganic & medicinal chemistry, 17(21), pp. 7435-40. Amsterdam: Elsevier 10.1016/j.bmc.2009.09.032
Dietrich, Silvia Anthoine; Lindauer, Renate; Stierlin, Claire; Gertsch, Jürg; Matesanz, Ruth; Notararigo, Sara; Díaz, José Fernando; Altmann, Karl-Heinz (2009). Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin. Chemistry - a European journal, 15(39), pp. 10144-57. Weinheim: Wiley-VCH 10.1002/chem.200901376
Oesch, Susanne; Gertsch, Jürg (2009). Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? Journal of pharmacy and pharmacology, 61(7), pp. 839-53. London: Royal Pharmaceutical Society of Great Britain 10.1211/jpp/61.07.0002
Pfeiffer, Bernhard; Hauenstein, Kurt; Merz, Philipp; Gertsch, Jürg; Altmann, Karl-Heinz (2009). Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. Bioorganic and medicinal chemistry letters, 19(14), pp. 3760-3. New York, N.Y.: Pergamon 10.1016/j.bmcl.2009.04.112
Gollner, Andreas; Altmann, Karl-Heinz; Gertsch, Jürg; Mulzer, Johann (2009). The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue. Chemistry - a European journal, 15(24), pp. 5979-97. Weinheim: Wiley-VCH 10.1002/chem.200802605
Chicca, Andrea; Raduner, Stefan; Pellati, Federica; Strompen, Thomas; Altmann, Karl-Heinz; Schoop, Roland; Gertsch, Jürg (2009). Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. International immunopharmacology, 9(7-8), pp. 850-8. Amsterdam: Elsevier 10.1016/j.intimp.2009.03.006
Gertsch, Jürg (2009). How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems. Journal of ethnopharmacology, 122(2), pp. 177-83. Shannon: Elsevier Science Ireland 10.1016/j.jep.2009.01.010
Markt, Patrick; Feldmann, Clemens; Rollinger, Judith Maria; Raduner, Stefan; Schuster, Daniela; Kirchmair, Johannes; Distinto, Simona; Spitzer, Gudrun Maria; Wolber, Gerhard; Laggner, Christian; Altmann, Karl-Heinz; Langer, Thierry; Gertsch, Jürg (2009). Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. Journal of medicinal chemistry, 52(2), pp. 369-78. Easton, Pa.: American Chemical Society 10.1021/jm801044g
Rollinger, Judith M; Schuster, Daniela; Danzl, Birgit; Schwaiger, Stefan; Markt, Patrick; Schmidtke, Michaela; Gertsch, Jürg; Raduner, Stefan; Wolber, Gerhard; Langer, Thierry; Stuppner, Hermann (2009). In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta medica, 75(3), pp. 195-204. Stuttgart: Thieme 10.1055/s-0028-1088397
Gertsch, Jürg; Feyen, Fabian; Bützberger, Alexander; Gerber, Barbara; Pfeiffer, Bernhard; Altmann, Karl-Heinz (2009). Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent N12-aza-epothilone (azathilone). ChemBioChem, 10(15), pp. 2513-21. Weinheim: Wiley-VCH 10.1002/cbic.200900376
Casagrande, Fabio; Harder, Daniel; Schenk, Andreas; Meury, Marcel; Ucurum, Zohre; Engel, Andreas; Weitz, Dietmar; Daniel, Hannelore; Fotiadis, Dimitrios (2009). Projection structure of DtpD (YbgH), a prokaryotic member of the peptide transporter family. Journal of molecular biology, 394(4), pp. 708-17. Amsterdam: Elsevier 10.1016/j.jmb.2009.09.048
Bippes, Christian A; Zeltina, Antra; Casagrande, Fabio; Ratera, Merce; Palacin, Manuel; Muller, Daniel J; Fotiadis, Dimitrios (2009). Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter. Journal of biological chemistry, 284(28), pp. 18651-63. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M109.004267
Jastrzebska, Beata; Golczak, Marcin; Fotiadis, Dimitrios; Engel, Andreas; Palczewski, Krzysztof (2009). Isolation and functional characterization of a stable complex between photoactivated rhodopsin and the G protein, transducin. FASEB journal, 23(2), pp. 371-81. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.07-114835
Bolanz, Katrin A; Kovacs, Gergely Gy; Landowski, Christopher P; Hediger, Matthias A (2009). Tamoxifen inhibits TRPV6 activity via estrogen receptor-independent pathways in TRPV6-expressing MCF-7 breast cancer cells. Molecular cancer research, 7(12), pp. 2000-10. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1541-7786.MCR-09-0188
Sigel, Erwin; Kaur, Kuldeep H; Lüscher, Benjamin P; Baur, Roland (2009). Use of concatamers to study GABAA receptor architecture and function: application to delta-subunit-containing receptors and possible pitfalls. Biochemical Society transactions, 37(Pt 6), pp. 1338-42. London: Portland Press 10.1042/BST0371338
Tan, Kelly R; Baur, Roland; Charon, Sébastien; Goeldner, Maurice; Sigel, Erwin (2009). Relative positioning of diazepam in the benzodiazepine-binding-pocket of GABA receptors. Journal of neurochemistry, 111(5), pp. 1264-73. Oxford: Wiley-Blackwell 10.1111/j.1471-4159.2009.06419.x
Baur, Roland; Kaur, Kuldeep H; Sigel, Erwin (2009). Structure of alpha6 beta3 delta GABA(A) receptors and their lack of ethanol sensitivity. Journal of neurochemistry, 111(5), pp. 1172-81. Oxford: Wiley-Blackwell 10.1111/j.1471-4159.2009.06387.x
Kaur, Kuldeep H; Baur, Roland; Sigel, Erwin (2009). Unanticipated structural and functional properties of delta-subunit-containing GABAA receptors. Journal of biological chemistry, 284(12), pp. 7889-96. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M806484200
Nichols, Buford L; Quezada-Calvillo, Roberto; Robayo-Torres, Claudia C; Ao, Zihua; Hamaker, Bruce R; Butte, Nancy F; Marini, Juan; Jahoor, Farook; Sterchi, Erwin E (2009). Mucosal maltase-glucoamylase plays a crucial role in starch digestion and prandial glucose homeostasis of mice. Journal of nutrition, 139(4), pp. 684-90. Bethesda, Md.: American Society for Nutrition 10.3945/jn.108.098434
Bergeron, Marc J; Frenette-Cotton, Rachelle; Carpentier, Gabriel A; Simard, Michael G; Caron, Luc; Isenring, Paul (2009). Phosphoregulation of K(+)-Cl(-) cotransporter 4 during changes in intracellular Cl(-) and cell volume. Journal of cellular physiology, 219(3), pp. 787-96. Hoboken, N.J.: Wiley 10.1002/jcp.21725
Wächter, Regula; Masarik, Lukas; Bürzle, Marc; Mallik, Ajit; von Mandach, Ursula (2009). Differential expression and activity of 11beta-hydroxysteroid dehydrogenase in human placenta and fetal membranes from pregnancies with intrauterine growth restriction. Fetal diagnosis and therapy, 25(3), pp. 328-35. Basel: Karger 10.1159/000235879
Gollner, A; Altmann, K.-H; Gertsch, J; Mulzer, J (2009). Synthesis and biological evaluation of a des-dihydropyran laulimalide analog. Tetrahedron letters, 50(42), pp. 5790-5792. Amsterdam: Elsevier 10.1016/j.tetlet.2009.07.122
Guertler, Patrick; Paul, Vijay; Albrecht, Christiane; Meyer, Heinrich H D (2009). Sensitive and highly specific quantitative real-time PCR and ELISA for recording a potential transfer of novel DNA and Cry1Ab protein from feed into bovine milk. Analytical and bioanalytical chemistry, 393(6-7), pp. 1629-38. Heidelberg: Springer 10.1007/s00216-009-2667-2
Mani, O; Sorensen, M T; Sejrsen, K; Bruckmaier, R M; Albrecht, C (2009). Differential expression and localization of lipid transporters in the bovine mammary gland during the pregnancy-lactation cycle. Journal of dairy science, 92(8), pp. 3744-56. Savoy, Ill.: American Dairy Science Association 10.3168/jds.2009-2063
Peinelt, Christine; Lis, Annette; Beck, Andreas; Fleig, Andrea; Penner, Reinhold (2008). 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. Journal of physiology, 586(13), pp. 3061-3073. Wiley-Blackwell 10.1113/jphysiol.2008.151365
Parvez, Suhel; Beck, Andreas; Peinelt, Christine; Soboloff, Jonathan; Lis, Annette; Monteilh-Zoller, Mahealani; Gill, Donald L; Fleig, Andrea; Penner, Reinhold (2008). STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB journal, 22(3), pp. 752-761. Federation of American Societies for Experimental Biology 10.1096/fj.07-9449com
Bollan, Karen A; Baur, Roland; Hales, Tim G; Sigel, Erwin; Connolly, Christopher N (2008). The promiscuous role of the epsilon subunit in GABA(A) receptor biogenesis. Molecular and cellular neuroscience, 37(3), pp. 610-621. San Diego, Calif.: Elsevier 10.1016/j.mcn.2007.12.011
Niggli, Verena; Sigel, Erwin (2008). Anticipating antiport in P-type ATPases. Trends in biochemical sciences, 33(4), pp. 156-60. Cambridge: Elsevier Current Trends 10.1016/j.tibs.2007.12.005
Farke, Carolin; Meyer, Heinrich H D; Bruckmaier, Rupert M; Albrecht, Christiane (2008). Differential expression of ABC transporters and their regulatory genes during lactation and dry period in bovine mammary tissue. Journal of dairy research, 75(4), pp. 406-14. London: Cambridge University Press 10.1017/S002202990800335X
Paul, Vijay; Meyer Heinrich, H D; Leidl, Katharina; Soumian, Soni; Albrecht, Christiane (2008). A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells. Journal of lipid research, 49(10), pp. 2259-67. Bethesda, Md.: American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.D700040-JLR200
Gürtler, P; Lutz, B; Kühn, R; Meyer, H.H.D.; Albrecht, C (2008). Fate of recombinant DNA and Cry1Ab protein after ingestion and dispersal of genetically modified maize in comparison to rapeseed by fallow deer (Dama dama). European journal of wildlife research, 54(2008), pp. 36-43. Berlin: Springer-Verlag 10.1007/s10344-007-0104-4
Casagrande, Fabio; Ratera, Merce; Schenk, Andreas D; Chami, Mohamed; Valencia, Eva; Lopez, Jesus Maria; Torrents, David; Engel, Andreas; Palacin, Manuel; Fotiadis, Dimitrios (2008). Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily. Journal of biological chemistry, 283(48), pp. 33240-8. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M806917200
Harder, Daniel; Stolz, Jürgen; Casagrande, Fabio; Obrdlik, Petr; Weitz, Dietmar; Fotiadis, Dimitrios; Daniel, Hannelore (2008). DtpB (YhiP) and DtpA (TppB, YdgR) are prototypical proton-dependent peptide transporters of Escherichia coli. FEBS journal, 275(13), pp. 3290-8. Oxford: Wiley-Blackwell 10.1111/j.1742-4658.2008.06477.x
Whorton, Matthew R; Jastrzebska, Beata; Park, Paul S-H; Fotiadis, Dimitrios; Engel, Andreas; Palczewski, Krzysztof; Sunahara, Roger K (2008). Efficient coupling of transducin to monomeric rhodopsin in a phospholipid bilayer. Journal of biological chemistry, 283(7), pp. 4387-94. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M703346200
Hoogenboom, B.W.; Frederix, P.L.T.M.; Fotiadis, D (2008). Potential of interferometric cantilever detection and its application for SFM/AFM in liquids. Nanotechnology, 19(38), p. 384019. Bristol, UK: Institute of Physics Publishing IOP 10.1088/0957-4484/19/38/384019
Bosshart, P.D.; Casagrande, F; Frederix, P.L.T.M.; Ratera, M; Bippes, C.A.; Müller, D.J.; Palacin, M; Engel, A; Fotiadis, D (2008). High-throughput single-molecule force spectroscopy for membrane proteins. Nanotechnology, 19(38), p. 384014. Bristol, UK: Institute of Physics Publishing IOP 10.1088/0957-4484/19/38/384014
Goldshmidt, Hanoch; Sheiner, Lilach; Bütikofer, Peter; Roditi, Isabel; Uliel, Shai; Günzel, Mark; Engstler, Markus; Michaeli, Shulamit (2008). Role of protein translocation pathways across the endoplasmic reticulum in Trypanosoma brucei. Journal of biological chemistry, 283(46), pp. 32085-32098. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M801499200
Signorell, Aita; Rauch, Monika; Jelk, Jennifer; Ferguson, Michael A J; Bütikofer, Peter (2008). Phosphatidylethanolamine in Trypanosoma brucei is organized in two separate pools and is synthesized exclusively by the Kennedy pathway. Journal of biological chemistry, 283(35), pp. 23636-44. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M803600200
Signorell, Aita; Jelk, Jennifer; Rauch, Monika; Bütikofer, Peter (2008). Phosphatidylethanolamine is the precursor of the ethanolamine phosphoglycerol moiety bound to eukaryotic elongation factor 1A. Journal of biological chemistry, 283(29), pp. 20320-9. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M802430200
Jaquenoud, Malika; Pagac, Martin; Signorell, Aita; Benghezal, Mohammed; Jelk, Jennifer; Bütikofer, Peter; Conzelmann, Andreas (2008). The Gup1 homologue of Trypanosoma brucei is a GPI glycosylphosphatidylinositol remodelase. Molecular microbiology, 67(1), pp. 202-12. Oxford: Blackwell Science 10.1111/j.1365-2958.2007.06043.x
Sterchi, Erwin E (2008). Special issue: metzincin metalloproteinases. Molecular aspects of medicine, 29(5), pp. 255-7. Amsterdam: Elsevier 10.1016/j.mam.2008.08.007
Ambort, Daniel; Lottaz, Daniel; Sterchi, Erwin (2008). Sample preparation of culture medium from Madin-Darby canine kidney cells. Methods in molecular biology, 425, pp. 113-130. Totowa, N.J.: Humana Press
Sterchi, Erwin E; Stöcker, Walter; Bond, Judith S (2008). Meprins, membrane-bound and secreted astacin metalloproteinases. Molecular aspects of medicine, 29(5), pp. 309-28. Amsterdam: Elsevier 10.1016/j.mam.2008.08.002
Bergin, David A; Greene, Catherine M; Sterchi, Erwin E; Kenna, Cliona; Geraghty, Patrick; Belaaouaj, Abderazzaq; Taggart, Clifford C; O'Neill, Shane J; McElvaney, Noel G (2008). Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. Journal of biological chemistry, 283(46), pp. 31736-44. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M803732200
Ambort, Daniel; Stalder, Daniel; Lottaz, Daniel; Huguenin, Maya; Oneda, Beatrice; Heller, Manfred; Sterchi, Erwin E (2008). A novel 2D-based approach to the discovery of candidate substrates for the metalloendopeptidase meprin. FEBS journal, 275(18), pp. 4490-509. Oxford: Wiley-Blackwell 10.1111/j.1742-4658.2008.06592.x
Oneda, Beatrice; Lods, Nadège; Lottaz, Daniel; Becker-Pauly, Christoph; Stöcker, Walter; Pippin, Jeffrey; Huguenin, Maya; Ambort, Daniel; Marti, Hans-Peter; Sterchi, Erwin E (2008). Metalloprotease meprin beta in rat kidney: glomerular localization and differential expression in glomerulonephritis. PLoS ONE, 3(5), e2278. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0002278
Huguenin, Maya; Müller, Eliane J; Trachsel-Rösmann, Sandra; Oneda, Beatrice; Ambort, Daniel; Sterchi, Erwin E; Lottaz, Daniel (2008). The metalloprotease meprinbeta processes E-cadherin and weakens intercellular adhesion. PLoS ONE, 3(5), e2153. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0002153
Quezada-Calvillo, Roberto; Sim, Lyann; Ao, Zihua; Hamaker, Bruce R; Quaroni, Andrea; Brayer, Gary D; Sterchi, Erwin E; Robayo-Torres, Claudia C; Rose, David R; Nichols, Buford L (2008). Luminal starch substrate "brake" on maltase-glucoamylase activity is located within the glucoamylase subunit. Journal of nutrition, 138(4), pp. 685-92. Bethesda, Md.: American Society for Nutrition
Sim, Lyann; Quezada-Calvillo, Roberto; Sterchi, Erwin E; Nichols, Buford L; Rose, David R (2008). Human intestinal maltase-glucoamylase: crystal structure of the N-terminal catalytic subunit and basis of inhibition and substrate specificity. Journal of molecular biology, 375(3), pp. 782-92. Amsterdam: Elsevier 10.1016/j.jmb.2007.10.069
Burgunder, Jean-Marc; Huifang, Shang; Beguin, Pascal; Baur, Roland; Eng, Chew Soh; Seet, Raymond C S; Lim, Erle C H; Ong, Benjamin K C; Hunziker, Walter; Sigel, Erwin (2008). Novel chloride channel mutations leading to mild myotonia among Chinese. Neuromuscular disorders, 18(8), pp. 633-40. Amsterdam: Elsevier 10.1016/j.nmd.2008.05.007
Baur, Roland; Tan, Kelly R; Lüscher, Benjamin P; Gonthier, Anne; Goeldner, Maurice; Sigel, Erwin (2008). Covalent modification of GABAA receptor isoforms by a diazepam analogue provides evidence for a novel benzodiazepine binding site that prevents modulation by these drugs. Journal of neurochemistry, 106(6), pp. 2353-63. Oxford: Wiley-Blackwell 10.1111/j.1471-4159.2008.05574.x
Sung, Ji-Min; Cho, Hee-Jung; Yi, Hee; Lee, Chi-Ho; Kim, Hye-Sun; Kim, Dong-Ku; Abd El-Aty, A M; Kim, Jin-Suk; Landowski, Christopher P; Hediger, Matthias A; Shin, Ho-Chul (2008). Characterization of a stem cell population in lung cancer A549 cells. Biochemical and biophysical research communications, 371(1), pp. 163-7. Orlando, Fla.: Academic Press 10.1016/j.bbrc.2008.04.038
Bergeron, M; Simonin, A; Bürzle, M; Hediger, M (2008). Inherited epithelial transporter disorders-an overview. Journal of inherited metabolic disease, 31(2), pp. 178-187. Lancaster, UK: Springer Netherlands 10.1007/s10545-008-0861-6
Suzuki, Yoshiro; Kovacs, Christopher S; Takanaga, Hitomi; Peng, Ji-Bin; Landowski, Christopher P; Hediger, Matthias A (2008). Calcium channel TRPV6 is involved in murine maternal-fetal calcium transport. Journal of bone and mineral research, 23(8), pp. 1249-56. Hoboken, N.J.: Wiley-Blackwell 10.1359/JBMR.080314
Suzuki, Yoshiro; Pasch, Andreas; Bonny, Olivier; Mohaupt, Markus G; Hediger, Matthias A; Frey, Felix J (2008). Gain-of-function haplotype in the epithelial calcium channel TRPV6 is a risk factor for renal calcium stone formation. Human molecular genetics, 17(11), pp. 1613-8. Oxford: Oxford University Press 10.1093/hmg/ddn048
Bolanz, Katrin A; Hediger, Matthias A; Landowski, Christopher P (2008). The role of TRPV6 in breast carcinogenesis. Molecular cancer therapeutics, 7(2), pp. 271-9. Philadelphia, Pa.: American Association for Cancer Research AACR 10.1158/1535-7163.MCT-07-0478
Mackenzie, Bryan; Illing, Anthony C; Hediger, Matthias A (2008). Transport model of the human Na+-coupled L-ascorbic acid (vitamin C) transporter SVCT1. American journal of physiology - cell physiology, 294(2), C451-9. Bethesda, Md.: American Physiological Society 10.1152/ajpcell.00439.2007
Suzuki, Yoshiro; Landowski, Christopher P; Hediger, Matthias A (2008). Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. Annual review of physiology, 70, pp. 257-271. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev.physiol.69.031905.161003
Benn, Bryan S; Ajibade, Dare; Porta, Angela; Dhawan, Puneet; Hediger, Matthias; Peng, Ji-Bin; Jiang, Yi; Oh, Goo Taeg; Jeung, Eui-Bae; Lieben, Liesbet; Bouillon, Roger; Carmeliet, Geert; Christakos, Sylvia (2008). Active intestinal calcium transport in the absence of transient receptor potential vanilloid type 6 and calbindin-D9k. Endocrinology, 149(6), pp. 3196-205. Chevy Chase, Md.: Endocrine Society 10.1210/en.2007-1655
Schütz, Patrick; Bumann, Mario; Oberholzer, Anselm Erich; Bieniossek, Christoph; Trachsel, Hans; Altmann, Michael; Baumann, Ulrich (2008). Crystal structure of the yeast eIF4A-eIF4G complex: an RNA-helicase controlled by protein-protein interactions. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 105(28), pp. 9564-9569. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0800418105
Lindqvist, Lisa; Oberer, Monika; Reibarkh, Mikhail; Cencic, Regina; Bordeleau, Marie-Eve; Vogt, Emily; Marintchev, Assen; Tanaka, Junichi; Fagotto, Francois; Altmann, Michael; Wagner, Gerhard; Pelletier, Jerry (2008). Selective pharmacological targeting of a DEAD box RNA helicase. PLoS ONE, 3(2), e1583. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0001583
Gertsch, Jürg; Leonti, Marco; Raduner, Stefan; Racz, Ildiko; Chen, Jian-Zhong; Xie, Xiang-Qun; Altmann, Karl-Heinz; Karsak, Meliha; Zimmer, Andreas (2008). Beta-caryophyllene is a dietary cannabinoid. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 105(26), pp. 9099-104. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0803601105
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