Wulfkuhle, Julia D; Berg, Daniela; Wolff, Claudia; Langer, Rupert; Tran, Kai; Illi, Julie; Espina, Virginia; Pierobon, Mariaelena; Deng, Jianghong; DeMichele, Angela; Walch, Axel; Bronger, Holger; Becker, Ingrid; Waldhör, Christine; Höfler, Heinz; Esserman, Laura; Liotta, Lance A; Becker, Karl-Friedrich; Petricoin, Emanuel F (2012). Molecular analysis of HER2 signaling in human breast cancer by functional protein pathway activation mapping. Clinical cancer research, 18(23), pp. 6426-35. Philadelphia, Pa.: American Association for Cancer Research 10.1158/1078-0432.CCR-12-0452
Full text not available from this repository.Targeting of the HER2 protein in human breast cancer represents a major advance in oncology but relies on measurements of total HER2 protein and not HER2 signaling network activation. We used reverse-phase protein microarrays (RPMA) to measure total and phosphorylated HER2 in the context of HER family signaling to understand correlations between phosphorylated and total levels of HER2 and downstream signaling activity.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Langer, Rupert |
ISSN: |
1078-0432 |
Publisher: |
American Association for Cancer Research |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:32 |
Last Modified: |
05 Dec 2022 14:10 |
Publisher DOI: |
10.1158/1078-0432.CCR-12-0452 |
PubMed ID: |
23045247 |
Web of Science ID: |
000312025600006 |
URI: |
https://boris.unibe.ch/id/eprint/12512 (FactScience: 218866) |
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