Haematological parameters are normal in dominant white Franches-Montagnes horses carrying a KIT mutation

Haase, Bianca; Obexer-Ruff, G.; Dolf, Gaudenz; Rieder, S.; Burger, D.; Poncet, P.A.; Gerber, Vinzenz; Howard, J.; Leeb, Tosso (2010). Haematological parameters are normal in dominant white Franches-Montagnes horses carrying a KIT mutation. Veterinary journal, 184(3), pp. 315-7. Amsterdam: Elsevier 10.1016/j.tvjl.2009.02.017

Full text not available from this repository. (Request a copy)

The KIT receptor protein-tyrosine kinase plays an important role during embryonic development. Activation of KIT is crucial for the development of various cell lineages such as melanoblasts, stem cells of the haematopoietic system, spermatogonia and intestinal cells of Cajal. In mice, many mutations in the Kit gene cause pigmentation disorders accompanied by pleiotropic effects on blood cells and male fertility. Previous work has demonstrated that dominant white Franches-Montagnes horses carry one copy of the KIT gene with the p.Y717X mutation. The targeted breeding of white horses would be ethically questionable if white horses were known to suffer from anaemia or leukopenia. The present study demonstrates that no statistically significant differences in peripheral blood parameters are detectable between dominant white and solid-coloured Franches-Montagnes horses. The data indicate that KIT mutations may have different effects in mice, pigs, and horses. The KIT p.Y717X mutation does not have a major negative effect on the haematopoietic system of dominant white horses.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Equine Clinic
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Central Clinical Laboratory

UniBE Contributor:

Haase, Bianca; Dolf, Gaudenz; Gerber, Vinzenz; Howard, Judith and Leeb, Tosso

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

1090-0233

Publisher:

Elsevier

Language:

English

Submitter:

Judith Howard

Date Deposited:

04 Oct 2013 14:32

Last Modified:

16 Feb 2015 08:47

Publisher DOI:

10.1016/j.tvjl.2009.02.017

Web of Science ID:

000278669100015

URI:

https://boris.unibe.ch/id/eprint/12517 (FactScience: 218871)

Actions (login required)

Edit item Edit item
Provide Feedback