Mechanisms of ATP Release by Inflammatory Cells.

Dosch, Michel; Gerber, Joël; Jebbawi, Fadi; Beldi, Guido (2018). Mechanisms of ATP Release by Inflammatory Cells. International journal of molecular sciences, 19(4) Molecular Diversity Preservation International MDPI 10.3390/ijms19041222

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Extracellular nucleotides (e.g., ATP, ADP, UTP, UDP) released by inflammatory cells interact with specific purinergic P2 type receptors to modulate their recruitment and activation. The focus of this review is on stimuli and mechanisms of extracellular nucleotide release and its consequences during inflammation. Necrosis leads to non-specific release of nucleotides, whereas specific release mechanisms include vesicular exocytosis and channel-mediated release via connexin or pannexin hemichannels. These release mechanisms allow stimulated inflammatory cells such as macrophages, neutrophils, and endothelial cells to fine-tune autocrine/paracrine responses during acute and chronic inflammation. Key effector functions of inflammatory cells are therefore regulated by purinergic signaling in acute and chronic diseases, making extracellular nucleotide release a promising target for the development of new therapies.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Dosch, Michel; Jebbawi, Fadi and Beldi, Guido

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-6596

Publisher:

Molecular Diversity Preservation International MDPI

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

10 Apr 2019 14:42

Last Modified:

10 Apr 2019 14:42

Publisher DOI:

10.3390/ijms19041222

PubMed ID:

29669994

Uncontrolled Keywords:

ATP release connexins endothelial cells extracellular nucleotides inflammation monocytes/macrophages neutrophils non-specific nucleotide release pannexins purinergic signaling vesicular exocytosis

BORIS DOI:

10.7892/boris.125784

URI:

https://boris.unibe.ch/id/eprint/125784

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