Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis.

Schlossberger, Viola; Worni, Mathias; Kihm, Christina; Montani, Matteo; Datz, Christian; Hampe, Jochen; Stickel, Felix (2019). Plasma Levels of K18 Fragments Do Not Correlate with Alcoholic Liver Fibrosis. Gut and liver, 13(1), pp. 77-82. Editorial Office of Gut and Liver 10.5009/gnl18037

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Background/Aims Noninvasive markers of liver fibrosis in alcoholic liver disease (ALD) are crucial to establish early intervention. Previous studies have suggested that plasma levels of cleaved keratin-18 (K18; M30) fragments can predict the severity of liver disease. The aim of this study was to correlate plasma M30 levels with stages of liver fibrosis in ALD. Methods Patients with ALD (n=139, 79.1% males) and liver histology were included, and plasma samples were collected to quantify plasma M30 levels. Patients were stratified into five groups by fibrosis stage (F0=14; F1=15; F2=35; F3=17; and F4=58) according to the Kleiner score. Differences between groups were evaluated using the chi-square test or analysis of variance. Trends by fibrosis stage were calculated by logistic regression analysis, and sensitivity, specificity and positive and negative predictive values were determined. Results There were no significant differences in M30 levels among fibrosis stages. The correlation between plasma M30 levels and fibrosis was poor (Pearson's correlation coefficient= 0.13, Spearman rho=0.20 [p=0.02]), and M30 levels did not correlate with alcohol-specific histological features. However, significant correlations of M30 levels with aspartate aminotransferase (Spearman rho=0.653, p<0.001) and alanine aminotransferase (spearman rho=0.432, p<0.001) were found. m30 levels of>200 U/L reveal a sensitivity for predicting cirrhosis of 84.5% with a negative predictive value of 73.5%. Conclusions Plasma M30 levels are often elevated in ALD and correlate with serum transaminases but do not reflect fibrosis. The usefulness as a prognostic marker awaits evaluation in prospective studies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

UniBE Contributor:

Worni, Mathias and Montani, Matteo

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2005-1212

Publisher:

Editorial Office of Gut and Liver

Language:

English

Submitter:

Lilian Karin Smith-Wirth

Date Deposited:

21 Feb 2019 13:58

Last Modified:

30 Oct 2019 05:50

Publisher DOI:

10.5009/gnl18037

PubMed ID:

29976035

Uncontrolled Keywords:

Apoptosis Caspases Fibrosis progression Noninvasive diagnosis

BORIS DOI:

10.7892/boris.125800

URI:

https://boris.unibe.ch/id/eprint/125800

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