Changing trends in international versus domestic HCV transmission in HIV-positive MSM: A perspective for the DAA scale-up era.

Salazar Vizcaya, Luisa Paola; Kouyos, Roger D; Metzner, Karin J; Caraballo Cortes, Kamila; Böni, Jürg; Shah, Cyril; Fehr, Jan; Braun, Dominique L; Bernasconi, Enos; Mbunkah, Herbert A; Hoffmann, Matthias; Labhardt, Niklaus; Cavassini, Matthias; Rougemont, Mathieu; Günthard, Huldrych F; Keiser, Olivia; Rauch, Andri (2019). Changing trends in international versus domestic HCV transmission in HIV-positive MSM: A perspective for the DAA scale-up era. The journal of infectious diseases, 220(1), pp. 91-99. Oxford University Press 10.1093/infdis/jiz069

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Background Scale-up of direct-acting antiviral(DAA) therapy is expected to abate HCV incidence among HIV-positive men-who-have-sex-with-men(MSM). Treatment programs in neighbouring countries may influence each other's outcomes through international transmission. We aimed at classifying HCV infections in HIV-positive MSM as either domestically or internationally acquired, and at estimating how this classification changed over time. Methods HCV subtype 1a (the most frequent subtype among MSM) genomes from 99 persons enrolled in the Swiss-HIV-Cohort-Study(SHCS) and diagnosed with replicating HCV infections between 1999 and 2016, were sequenced. Sixty-six of these sequences were from MSM. We inferred maximum-likelihood phylogenetic-trees and time-trees containing a fragment of the NS5B region of these and other 374 circulating strains retrieved from national and international databases. We inferred transmission clusters from these trees and used the country composition of such clusters to attribute infections to domestic or international transmission. Results Fifty to 80% of HCV transmissions were classified as domestic depending on the classification criterion. Between 2000 and 2007, the fraction attributable to domestic transmission was 54%[range:0%-75%]. It increased to 85%[range:67%-100%] between 2008 and 2016. Conclusions International and domestic transmission have played major roles in the epidemic. While international transmission persists, local transmission has established as the main source of infections.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Salazar Vizcaya, Luisa Paola and Rauch, Andri

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1537-6613

Publisher:

Oxford University Press

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

12 Apr 2019 16:43

Last Modified:

14 Feb 2020 02:30

Publisher DOI:

10.1093/infdis/jiz069

PubMed ID:

30759225

BORIS DOI:

10.7892/boris.126883

URI:

https://boris.unibe.ch/id/eprint/126883

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