Role of Rifampin against Staphylococcal Biofilm Infections , in Animal Models, and in Orthopedic-Device-Related Infections.

Zimmerli, Werner; Sendi, Parham (2019). Role of Rifampin against Staphylococcal Biofilm Infections , in Animal Models, and in Orthopedic-Device-Related Infections. Antimicrobial agents and chemotherapy, 63(2) American Society for Microbiology 10.1128/AAC.01746-18

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Rifampin has been used as an agent in combination therapy in orthopedic device-related infections (ODRI) for almost three decades. The aim of this review is to provide data regarding the role of rifampin against biofilm infection , in animal models, and in clinical ODRI. Available data are gathered in order to present the rational use of rifampin combinations in patients with periprosthetic joint infection (PJI). The role of rifampin is well defined in patients with PJI and is indicated in those who fulfill the Infectious Diseases Society of America criteria for debridement and implant retention or one-stage exchange. It should be used with care because of the danger of rapid emergence of resistance. Potential drug interactions should be considered.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Sendi, Parham

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0066-4804

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Parham Sendi

Date Deposited:

27 Nov 2019 16:30

Last Modified:

27 Nov 2019 16:30

Publisher DOI:

10.1128/AAC.01746-18

PubMed ID:

30455229

Uncontrolled Keywords:

Staphylococcus prosthetic joint infection rifampin

BORIS DOI:

10.7892/boris.127213

URI:

https://boris.unibe.ch/id/eprint/127213

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