Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response.

Francica, Paola; Rottenberg, Sven (2018). Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response. Genome medicine, 10(1), p. 101. BioMed Central 10.1186/s13073-018-0612-8

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Inhibitors of poly(ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients with cancers that lack homology-directed DNA repair, but drug resistance remains a clinical hurdle. Recent advances in the identification of PARPi resistance mechanisms have yielded a better understanding of DNA end protection and the relevance of endogenous poly(ADP-ribose) glycohydrolase, highlighting new vulnerabilities.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Francica, Paola and Rottenberg, Sven

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 630 Agriculture

ISSN:

1756-994X

Publisher:

BioMed Central

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

29 May 2019 13:17

Last Modified:

28 Oct 2019 07:47

Publisher DOI:

10.1186/s13073-018-0612-8

PubMed ID:

30593284

BORIS DOI:

10.7892/boris.127528

URI:

https://boris.unibe.ch/id/eprint/127528

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