Francica, Paola; Rottenberg, Sven (2018). Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response. Genome medicine, 10(1), p. 101. BioMed Central 10.1186/s13073-018-0612-8
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Inhibitors of poly(ADP-ribose) polymerase (PARPi) have entered the clinic for the treatment of patients with cancers that lack homology-directed DNA repair, but drug resistance remains a clinical hurdle. Recent advances in the identification of PARPi resistance mechanisms have yielded a better understanding of DNA end protection and the relevance of endogenous poly(ADP-ribose) glycohydrolase, highlighting new vulnerabilities.
Item Type: |
Journal Article (Further Contribution) |
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Division/Institute: |
05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) |
UniBE Contributor: |
Francica, Paola, Rottenberg, Sven |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health 600 Technology > 630 Agriculture |
ISSN: |
1756-994X |
Publisher: |
BioMed Central |
Language: |
English |
Submitter: |
Pamela Schumacher |
Date Deposited: |
29 May 2019 13:17 |
Last Modified: |
05 Dec 2022 15:27 |
Publisher DOI: |
10.1186/s13073-018-0612-8 |
PubMed ID: |
30593284 |
BORIS DOI: |
10.7892/boris.127528 |
URI: |
https://boris.unibe.ch/id/eprint/127528 |
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