Detection and Characterization of Okapi (Okapia johnstoni)—specific Papillomavirus type 1 (OjPV1)

Ramsauer, Anna Sophie; Kubacki, Jakub; Welle, Monika Maria; Bachofen, Claudia; Fraefel, Cornel; Hoby, Stefan; Tobler, Kurt; Wenker, Christian (2018). Detection and Characterization of Okapi (Okapia johnstoni)—specific Papillomavirus type 1 (OjPV1). Veterinary microbiology, 223, pp. 113-118. Elsevier 10.1016/j.vetmic.2018.08.010

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Papillomavirus-specific DNA was detected in skin lesions collected from an okapi (Okapia johnstoni) in the Zoo Basel. According to the nucleotide sequence analysis, the virus belongs to the genus Deltapapillomavirus. Based on bioinformatics analysis, we propose to designate the newly identified virus as Okapia johnstoni Papillomavirus type 1 (OjPV1). OjPV1 is genetically most closely related to a recently described giraffe (Giraffa camelopardalis) -specific papillomavirus (GcPV1). Of note, the putative oncogenic E5 proteins from OjPV1 and GcPV1 are more conserved than the L1 proteins. This indicates, that the selection pressure on E5 may be more pronounced than that on the otherwise most conserved major capsid protein L1.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > DermFocus
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Welle, Monika Maria

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0378-1135

Publisher:

Elsevier

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

03 Jun 2019 11:36

Last Modified:

04 Nov 2019 18:08

Publisher DOI:

10.1016/j.vetmic.2018.08.010

PubMed ID:

30173736

BORIS DOI:

10.7892/boris.127554

URI:

https://boris.unibe.ch/id/eprint/127554

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