Detection and Characterization of Okapi (Okapia johnstoni)—specific Papillomavirus type 1 (OjPV1)

Ramsauer, Anna Sophie; Kubacki, Jakub; Welle, Monika Maria; Bachofen, Claudia; Fraefel, Cornel; Hoby, Stefan; Tobler, Kurt; Wenker, Christian (2018). Detection and Characterization of Okapi (Okapia johnstoni)—specific Papillomavirus type 1 (OjPV1). Veterinary microbiology, 223, pp. 113-118. Elsevier 10.1016/j.vetmic.2018.08.010

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Papillomavirus-specific DNA was detected in skin lesions collected from an okapi (Okapia johnstoni) in the Zoo Basel. According to the nucleotide sequence analysis, the virus belongs to the genus Deltapapillomavirus. Based on bioinformatics analysis, we propose to designate the newly identified virus as Okapia johnstoni Papillomavirus type 1 (OjPV1). OjPV1 is genetically most closely related to a recently described giraffe (Giraffa camelopardalis) -specific papillomavirus (GcPV1). Of note, the putative oncogenic E5 proteins from OjPV1 and GcPV1 are more conserved than the L1 proteins. This indicates, that the selection pressure on E5 may be more pronounced than that on the otherwise most conserved major capsid protein L1.

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