Feline Injection Site Sarcomas: Data from Switzerland 2009-2014.

Graf, R; Guscetti, F; Welle, Monika Maria; Meier, D; Pospischil, A (2018). Feline Injection Site Sarcomas: Data from Switzerland 2009-2014. Journal of comparative pathology, 163, pp. 1-5. Elsevier 10.1016/j.jcpa.2018.06.008

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Feline injection site sarcomas (FISS) were first described in the early 1990s. Despite extensive research, the pathogenesis of these tumours has not been elucidated conclusively. Their appearance and the marked increase in their incidence has been mainly connected to the injection of vaccines, and it is assumed that a chronic inflammatory reaction at the injection site triggers subsequent malignant transformation. The role of alum-based adjuvants has been discussed, but is controversial. The present study of the Swiss Feline Cancer Registry (SFCR) with data from 2009 to 2014 revealed a marked decrease of the incidence of fibrosarcomas compared with the previous observation period. Notably, this drop occurred after a non-adjuvanted feline leukaemia virus vaccine was introduced in Switzerland in 2007. This observation, together with the previous findings of the SFCR, further supports the notion that alum-adjuvanted vaccines are involved in the genesis of FISS and that non-adjuvanted vaccines might be safer for cats.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Animal Pathology
05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)

UniBE Contributor:

Welle, Monika Maria

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0021-9975

Publisher:

Elsevier

Language:

English

Submitter:

Achim Braun Parham

Date Deposited:

29 May 2019 14:05

Last Modified:

24 Oct 2019 19:33

Publisher DOI:

10.1016/j.jcpa.2018.06.008

PubMed ID:

30213367

Uncontrolled Keywords:

cat feline leukaemia virus fibrosarcoma vaccine

BORIS DOI:

10.7892/boris.127555

URI:

https://boris.unibe.ch/id/eprint/127555

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