Single-cell analysis of tumors: Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells.

Radpour, Ramin; Forouharkhou, Farzad (2018). Single-cell analysis of tumors: Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells. World journal of stem cells, 10(11), pp. 160-171. Baishideng Publishing Group 10.4252/wjsc.v10.i11.160

[img]
Preview
Text
WJSC-10-160.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC).

Download (1MB) | Preview

Biomarker-driven individualized treatment in oncology has made tremendous progress through technological developments, new therapeutic modalities and a deeper understanding of the molecular biology for tumors, cancer stem cells and tumor-infiltrating immune cells. Recent technical developments have led to the establishment of a variety of cancer-related diagnostic, prognostic and predictive biomarkers. In this regard, different modern OMICs approaches were assessed in order to categorize and classify prognostically different forms of neoplasia. Despite those technical advancements, the extent of molecular heterogeneity at the individual cell level in human tumors remains largely uncharacterized. Each tumor consists of a mixture of heterogeneous cell types. Therefore, it is important to quantify the dynamic cellular variations in order to predict clinical parameters, such as a response to treatment and or potential for disease recurrence. Recently, single-cell based methods have been developed to characterize the heterogeneity in seemingly homogenous cancer cell populations prior to and during treatment. In this review, we highlight the recent advances for single-cell analysis and discuss the challenges and prospects for molecular characterization of cancer cells, cancer stem cells and tumor-infiltrating immune cells.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Radpour, Ramin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1948-0210

Publisher:

Baishideng Publishing Group

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

12 Apr 2019 11:18

Last Modified:

22 Oct 2019 19:21

Publisher DOI:

10.4252/wjsc.v10.i11.160

PubMed ID:

30631391

Uncontrolled Keywords:

Cancer biomarkers Cancer cells Cancer stem cells Single-cell analysis Tumor-infiltrating lymphocytes

BORIS DOI:

10.7892/boris.127704

URI:

https://boris.unibe.ch/id/eprint/127704

Actions (login required)

Edit item Edit item
Provide Feedback