Molecular cloning and characterization of equine thymic stromal lymphopoietin

Klukowska-Rötzler, Jolanta; Marti, Eliane Isabelle; Bugno, M.; Leeb, Tosso; Janda, Jozef (2010). Molecular cloning and characterization of equine thymic stromal lymphopoietin. Veterinary immunology and immunopathology, 136(3-4), pp. 346-9. Amsterdam: Elsevier 10.1016/j.vetimm.2010.03.021

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Thymic stromal lymphopoietin (TSLP) is a novel cytokine that plays a central role in T helper 2 (Th2) cell differentiation and allergic inflammation. It is predominantly expressed by epithelial cells, and its expression is increased in patients with atopic dermatitis and asthma. Mice overexpressing TSLP in the skin develop allergic dermatitis and mice overexpressing TSLP in lungs develop asthma-like disease. However, it is not known whether TSLP plays an important role in equine allergies. Therefore, we cloned and sequenced the complete translated region of equine TSLP gene and measured its expression in various tissues. The equine TSLP gene is organized in 4 exons and encodes a protein of 143 amino acids, which has 62% amino acid identity with human TSLP.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DVK - Clinical Research [discontinued]

UniBE Contributor:

Klukowska, Jolanta; Marti, Eliane Isabelle; Leeb, Tosso and Janda, Jozef

Subjects:

500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture

ISSN:

0165-2427

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:33

Last Modified:

16 Feb 2015 08:53

Publisher DOI:

10.1016/j.vetimm.2010.03.021

Web of Science ID:

000280511500022

URI:

https://boris.unibe.ch/id/eprint/12798 (FactScience: 219270)

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