Changing Epidemiology of HCC: How to Screen and Identify Patients at Risk?

Lange, Franziska Naomi; Dufour, Jean-François (2019). Changing Epidemiology of HCC: How to Screen and Identify Patients at Risk? Digestive diseases and sciences, 64(4), pp. 903-909. Springer 10.1007/s10620-019-05515-8

[img] Text
Lange, Dig Dis Sci 2019.pdf - Published Version
Restricted to registered users only until 13 March 2023.
Available under License Publisher holds Copyright.

Download (798kB) | Request a copy

The prognosis of patients with hepatocellular carcinoma is dependent on the stage of tumor at diagnosis. The earlier the tumor is found, the higher the chances to offer a curative treatment. In order to diagnose hepatocellular carcinoma early, patients at risk should be enrolled in a surveillance program. The population at risk is usually defined as patients with cirrhosis. These patients should have twice a year a ultrasonographic examination of the liver. However, more and more patients will develop hepatocellular carcinoma in the context of nonalcoholic fatty liver disease which is tightly linked to obesity and diabetes. In these patients, this approach is jeopardized by the difficulty to perform a sonography of good quality due to the obesity and more importantly by the fact that hepatocellular carcinoma occurs frequently in the context of nonalcoholic fatty liver disease before the cirrhosis. This article reviews the impact of the changing epidemiology of hepatocellular carcinoma on its screening.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine

UniBE Contributor:

Lange, Franziska Naomi and Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1573-2568

Publisher:

Springer

Language:

English

Submitter:

Christine Baumgartner

Date Deposited:

25 Jun 2019 13:51

Last Modified:

23 Oct 2019 08:28

Publisher DOI:

10.1007/s10620-019-05515-8

PubMed ID:

30863952

Uncontrolled Keywords:

Epidemiology Hepatocellular carcinoma Liver cancer Population at risk Surveillance

BORIS DOI:

10.7892/boris.129259

URI:

https://boris.unibe.ch/id/eprint/129259

Actions (login required)

Edit item Edit item
Provide Feedback