Ultrasmall superparamagnetic particles of iron oxide allow for the detection of metastases in normal sized pelvic lymph nodes of patients with bladder and/or prostate cancer

Triantafyllou, Maria; Studer, Urs E.; Birkhäuser, Frédéric D.; Fleischmann, Achim; Bains, Lauren J.; Petralia, Giuseppe; Christe, Andreas; Fröhlich, Johannes M.; Thoeny, Harriet C. (2013). Ultrasmall superparamagnetic particles of iron oxide allow for the detection of metastases in normal sized pelvic lymph nodes of patients with bladder and/or prostate cancer. European journal of cancer, 49(3), pp. 616-624. Amsterdam: Elsevier 10.1016/j.ejca.2012.09.034

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Lymph node metastases influence prognosis and outcome in patients with bladder and prostate cancer. Cross sectional imaging criteria are limited in detecting metastases in normal sized lymph nodes. This prospective study assessed the diagnostic accuracy of ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) for the detection of metastases in normal sized lymph nodes using extended pelvic lymph node dissection (ePLND) and histopathology as the reference standard.

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