Molecular architecture of the presynaptic terminal

Zuber, Benoît; Lučić, Vladan (2019). Molecular architecture of the presynaptic terminal. Current opinion in structural biology, 54, pp. 129-138. Elsevier 10.1016/j.sbi.2019.01.008

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Neurotransmitter release at the presynaptic terminal is one of the fundamental processes in neuronal communication. It is a complex process comprising signaling pathways that exert a precise spatio-temporal coordination to prepare and bring synaptic vesicles to exocytosis. While many molecular components involved have been identified, their direct observation at different stages of the neurotransmitter release is lacking. Three-dimensional imaging by electron tomography provided remarkable views of the synaptic vesicles and the cytomatrix. Imaging fully hydrated, vitrified samples allowed a direct visualization, precise localization and a quantitative characterization of pleomorphic synaptic vesicle-bound complexes in situ, as well as the elucidation of their function in the neurotransmitter release.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
09 Interdisciplinary Units > Microscopy Imaging Center (MIC)

UniBE Contributor:

Zuber, Benoît

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0959-440X

Publisher:

Elsevier

Language:

English

Submitter:

Benoît Zuber

Date Deposited:

25 Jun 2019 13:42

Last Modified:

24 Oct 2019 07:35

Publisher DOI:

10.1016/j.sbi.2019.01.008

PubMed ID:

30925443

BORIS DOI:

10.7892/boris.129865

URI:

https://boris.unibe.ch/id/eprint/129865

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