Zuber, Benoît; Lučić, Vladan (2019). Molecular architecture of the presynaptic terminal. Current opinion in structural biology, 54, pp. 129-138. Elsevier 10.1016/j.sbi.2019.01.008
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Neurotransmitter release at the presynaptic terminal is one of the fundamental processes in neuronal communication. It is a complex process comprising signaling pathways that exert a precise spatio-temporal coordination to prepare and bring synaptic vesicles to exocytosis. While many molecular components involved have been identified, their direct observation at different stages of the neurotransmitter release is lacking. Three-dimensional imaging by electron tomography provided remarkable views of the synaptic vesicles and the cytomatrix. Imaging fully hydrated, vitrified samples allowed a direct visualization, precise localization and a quantitative characterization of pleomorphic synaptic vesicle-bound complexes in situ, as well as the elucidation of their function in the neurotransmitter release.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy 09 Interdisciplinary Units > Microscopy Imaging Center (MIC) |
UniBE Contributor: |
Zuber, Benoît |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0959-440X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Benoît Zuber |
Date Deposited: |
25 Jun 2019 13:42 |
Last Modified: |
05 Dec 2022 15:28 |
Publisher DOI: |
10.1016/j.sbi.2019.01.008 |
PubMed ID: |
30925443 |
BORIS DOI: |
10.7892/boris.129865 |
URI: |
https://boris.unibe.ch/id/eprint/129865 |
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