Do clinical investigations predict long-term wheeze? A follow-up of pediatric respiratory outpatients.

de Jong, Carmen C. M.; Pedersen, Eva SL.; Goutaki, Myrofora; Trachsel, Daniel; Barben, Juerg; Kuehni, Claudia E (2019). Do clinical investigations predict long-term wheeze? A follow-up of pediatric respiratory outpatients. Pediatric pulmonology, 54(8), pp. 1156-1161. Wiley-Blackwell 10.1002/ppul.24347

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The contribution of clinical investigations to prediction of long-term outcomes of children investigated for asthma is unclear.


We performed a broad range of clinical tests and investigated whether they helped to predict long-term wheeze among children referred for evaluation of possible asthma.


We studied children aged 6 to 16 years referred to two Swiss pulmonary outpatient clinics with a history of wheeze, dyspnea, or cough in 2007. The initial assessment included spirometry, fractional exhaled nitric oxide, skin prick tests, and bronchial provocation tests by exercise, methacholine, and mannitol. Respiratory symptoms were assessed with questionnaires at baseline and at follow-up 7 years later. Associations between baseline factors and wheeze at follow-up were investigated by logistic regression.


At baseline, 111 children were examined in 2007. After 7 years, 85 (77%) completed the follow-up questionnaire, among whom 61 (72%) had wheeze at baseline, while at follow-up 39 (46%) reported wheeze. Adjusting for age and sex, the following characteristics predicted wheeze at adolescence: wheeze triggered by pets (odds ratio, 4.2; 95% CI, 1.2-14.8), pollen (2.8, 1.1-7.0), and exercise (3.1, 1.2-8.0). Of the clinical tests, only a positive exercise test (3.2, 1.1-9.7) predicted wheeze at adolescence.


Reported exercise-induced wheeze and wheeze triggered by pets or pollen were important predictors of wheeze persistence into adolescence. None of the clinical tests predicted wheeze more strongly than reported symptoms. Clinical tests might be important for asthma diagnosis but medical history is more helpful in predicting prognosis in children referred for asthma.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)
Graduate School for Health Sciences (GHS)

UniBE Contributor:

de Jong, Carmen Cornelia Maria, Pedersen, Eva Sophie Lunde, Goutaki, Myrofora, Kühni, Claudia


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Anette van Dorland

Date Deposited:

08 May 2019 11:18

Last Modified:

05 Dec 2022 15:28

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

asthma cohort epidemiology prognosis respiratory wheeze




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