Pulmonary artery pressure at rest and during exercise in Chronic Mountain Sickness: a meta-analysis.

Soria, Rodrigo; Egger, Matthias; Scherrer, Urs; Bender, Nicole; Rimoldi, Stefano F (2019). Pulmonary artery pressure at rest and during exercise in Chronic Mountain Sickness: a meta-analysis. European respiratory journal, 53(6) European Respiratory Society 10.1183/13993003.02040-2018

[img] Text
Soria EurRespirJ 2019_epub.pdf - Accepted Version
Restricted to registered users only until 26 October 2020.
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy

Among the >140 million dwellers worldwide up to 10% suffer from chronic mountain sickness (CMS). Patients suffering from this debilitating problem often display increased pulmonary artery pressure (PAP) which may contribute to exercise intolerance and right heart failure. However, there is little information on the usual PAP in these patients.We systematically reviewed and meta-analyzed all data published in English or Spanish until June 2018 on echocardiographic estimations of PAP at rest and during mild exercise in CMS patients.Nine studies, comprising 287 participants fulfilled the inclusion criteria. At rest, the point estimate from meta-analysis of the mean systolic PAP was 28.0 mmHg [95% confidence interval (CI) 26.3, 29.6]. These values are 11% (+2.7 mmHg) higher than those recently meta-analysed in apparently healthy high-altitude dwellers (J Appl Physiol 121:1151-9, 2016). During mild exercise (50 W) the difference in mean systolic PAP between patients and high-altitude dwellers was markedly more accentuated (48.3 36.3 mmHg) than at rest.These findings indicate that in patients with CMS PAP is moderately increased at rest, but markedly increased during mild exercise, which will be common with activities of daily living.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Kardiologie

UniBE Contributor:

Soria Maldonado, Rodrigo; Egger, Matthias; Scherrer, Urs; Bender, Nicole and Rimoldi, Stefano

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
700 Arts

ISSN:

0903-1936

Publisher:

European Respiratory Society

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

08 May 2019 11:30

Last Modified:

24 Oct 2019 03:52

Publisher DOI:

10.1183/13993003.02040-2018

PubMed ID:

31023845

Additional Information:

Bender and Rimoldi contributed equally to this work.

BORIS DOI:

10.7892/boris.130390

URI:

https://boris.unibe.ch/id/eprint/130390

Actions (login required)

Edit item Edit item
Provide Feedback