The impact of ganglion cell layer cysts in diabetic macular oedema treated with anti-vascular endothelial growth factor.

Ceklic, Lala; Huf, Wolfgang; Ebneter, Andreas; Wolf, Sebastian; Zinkernagel, Martin; Munk, Marion (2019). The impact of ganglion cell layer cysts in diabetic macular oedema treated with anti-vascular endothelial growth factor. (In Press). Acta ophthalmologica Wiley 10.1111/aos.14137

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PURPOSE To investigate the prevalence and impact of ganglion cell layer cysts (GCLC) in patients with diabetic macular oedema (DME) under continuous anti-vascular endothelial growth factor (VEGF) therapy. METHODS The clinical findings and spectral domain optical coherence devices of baseline visits and follow-up after 12-24 and 36 months of DME patients under continuous anti-VEGF therapy were retrospectively collected and analysed for the impact of GCLC cysts. Previously established prognostic parameters were also assessed. RESULTS A total of 110 eyes of 110 DME patients (mean age 64 ± 10 years) were included. At baseline, 17% eyes had GCLC. With GCLC, the best-corrected visual acuity (BCVA) improvement was in mean 8.4 ± 2.4 Early-Treatment-Diabetic-Retinopathy-Study (ETDRS) letters less over the course of 36 months compared to the group lacking GCLC (p = 0.0009). Eyes with GCLC showed 68 ± 23.4 μm less central retinal thickness (CRT) decrease than eyes lacking GCLC (p < 0.0001). In the linear mixed effect models including external limiting membrane disruption, disintegration of inner retinal layer and epiretinal membrane, GCLC remained a statistical significant factor for the outcome parameter CRT, but missed statistical significance for BCVA. CONCLUSION Ganglion cell layer cysts (GCLC) seem to impact outcome in DME in patients receiving long-term treatment. This prognostic factor warrants further evaluation in the context of already well-established outcome parameters.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde

UniBE Contributor:

Ebneter, Andreas; Wolf, Sebastian; Zinkernagel, Martin and Munk, Marion

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1755-3768

Publisher:

Wiley

Language:

English

Submitter:

Marion Munk

Date Deposited:

19 Jul 2019 09:24

Last Modified:

23 Oct 2019 04:21

Publisher DOI:

10.1111/aos.14137

PubMed ID:

31099498

Uncontrolled Keywords:

anti-VEGF cysts diabetic macular oedema retinal ganglion cell layer

BORIS DOI:

10.7892/boris.130740

URI:

https://boris.unibe.ch/id/eprint/130740

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