Ceklic, Lala; Huf, Wolfgang; Ebneter, Andreas; Wolf, Sebastian; Zinkernagel, Martin; Munk, Marion (2019). The impact of ganglion cell layer cysts in diabetic macular oedema treated with anti-vascular endothelial growth factor. Acta ophthalmologica, 97(8), e1041-e1047. Wiley 10.1111/aos.14137
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PURPOSE
To investigate the prevalence and impact of ganglion cell layer cysts (GCLC) in patients with diabetic macular oedema (DME) under continuous anti-vascular endothelial growth factor (VEGF) therapy.
METHODS
The clinical findings and spectral domain optical coherence devices of baseline visits and follow-up after 12-24 and 36 months of DME patients under continuous anti-VEGF therapy were retrospectively collected and analysed for the impact of GCLC cysts. Previously established prognostic parameters were also assessed.
RESULTS
A total of 110 eyes of 110 DME patients (mean age 64 ± 10 years) were included. At baseline, 17% eyes had GCLC. With GCLC, the best-corrected visual acuity (BCVA) improvement was in mean 8.4 ± 2.4 Early-Treatment-Diabetic-Retinopathy-Study (ETDRS) letters less over the course of 36 months compared to the group lacking GCLC (p = 0.0009). Eyes with GCLC showed 68 ± 23.4 μm less central retinal thickness (CRT) decrease than eyes lacking GCLC (p < 0.0001). In the linear mixed effect models including external limiting membrane disruption, disintegration of inner retinal layer and epiretinal membrane, GCLC remained a statistical significant factor for the outcome parameter CRT, but missed statistical significance for BCVA.
CONCLUSION
Ganglion cell layer cysts (GCLC) seem to impact outcome in DME in patients receiving long-term treatment. This prognostic factor warrants further evaluation in the context of already well-established outcome parameters.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Augenklinik > Forschungsgruppe Augenheilkunde |
UniBE Contributor: |
Ebneter, Andreas, Wolf, Sebastian (B), Zinkernagel, Martin Sebastian, Munk, Marion |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1755-3768 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Marion Munk |
Date Deposited: |
19 Jul 2019 09:24 |
Last Modified: |
02 Mar 2023 23:32 |
Publisher DOI: |
10.1111/aos.14137 |
PubMed ID: |
31099498 |
Uncontrolled Keywords: |
anti-VEGF cysts diabetic macular oedema retinal ganglion cell layer |
BORIS DOI: |
10.7892/boris.130740 |
URI: |
https://boris.unibe.ch/id/eprint/130740 |
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