Mass Spectrometric Investigation of the Interaction of Metallocenes with Biomolecules

Bruni, Pia Simona; Schürch, Stefan (11 April 2019). Mass Spectrometric Investigation of the Interaction of Metallocenes with Biomolecules. In: CHanalysis. Swiss Chemical Society, Division of Analytical Sciences

Bent Metallocenes (Cp2MCl2) have fond wide interest as anticancer agents with DNA as possible target. One serious drawback is the low solubility in water and, in case of titanocene, the instability to hydrolysis of the cyclopentadienyl ligand at physiological pH leading to inactivation. In recent literature, cyclodextrins and cucurbiturils are proposed as host molecules to overcome these drawbacks, especially to protect the Cp ligands in titanocene from getting lost. These findings are based mainly on molecular modelling, solid-state structure investigation, and NMR measurements. Therefore, mass spectrometry may give complementary insight into the benefit of such host guest structures as drug delivery systems.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Bruni, Pia Simona and Schürch, Stefan

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry
500 Science

Publisher:

Swiss Chemical Society, Division of Analytical Sciences

Language:

English

Submitter:

Stefan Schürch

Date Deposited:

24 Jul 2019 10:42

Last Modified:

24 Jul 2019 10:42

URI:

https://boris.unibe.ch/id/eprint/131469

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