Microbial network disturbances in relapsing refractory Crohn's disease.

Yilmaz, Bahtiyar; Juillerat, Pascal; Øyås, Ove; Ramon, Charlotte; Bravo, Francisco Damian; Franc, Yannick; Fournier, Nicolas; Michetti, Pierre; Müller, Christoph; Geuking, Markus; Pittet, Valerie E H; Maillard, Michel H; Rogler, Gerhard; Wiest, Reiner; Stelling, Jörg; Macpherson, Andrew J (2019). Microbial network disturbances in relapsing refractory Crohn's disease. Nature medicine, 25(2), pp. 323-336. Nature Publishing Group 10.1038/s41591-018-0308-z

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Inflammatory bowel diseases (IBD) can be broadly divided into Crohn's disease (CD) and ulcerative colitis (UC) from their clinical phenotypes. Over 150 host susceptibility genes have been described, although most overlap between CD, UC and their subtypes, and they do not adequately account for the overall incidence or the highly variable severity of disease. Replicating key findings between two long-term IBD cohorts, we have defined distinct networks of taxa associations within intestinal biopsies of CD and UC patients. Disturbances in an association network containing taxa of the Lachnospiraceae and Ruminococcaceae families, typically producing short chain fatty acids, characterize frequently relapsing disease and poor responses to treatment with anti-TNF-α therapeutic antibodies. Alterations of taxa within this network also characterize risk of later disease recurrence of patients in remission after the active inflamed segment of CD has been surgically removed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Yilmaz, Bahtiyar; Juillerat, Pascal; Bravo, Francisco Damian; Müller, Christoph; Geuking, Markus and Wiest, Reiner

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

1078-8956

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Christa Hagert

Date Deposited:

20 Aug 2019 13:42

Last Modified:

09 Jan 2020 12:03

Publisher DOI:

10.1038/s41591-018-0308-z

PubMed ID:

30664783

Additional Information:

Uni-Be Authors Susanne Schibli, Johannes Spalinger, and Christiane Sokollik are explicitly mentioned as Contributors of the Swiss IBD Cohort Study Group.

BORIS DOI:

10.7892/boris.132129

URI:

https://boris.unibe.ch/id/eprint/132129

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