Measurement of pancreatic stone protein in the identification and management of sepsis.

Eggimann, Philippe; Que, Yok-Ai; Rebeaud, Fabien (2019). Measurement of pancreatic stone protein in the identification and management of sepsis. Biomarkers in medicine, 13(2), pp. 135-145. Future Medicine 10.2217/bmm-2018-0194

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Sepsis is a life-threatening syndrome characterized by a dysregulated host response to an infection resulting in multiple organ dysfunctions. Early diagnosis and management of sepsis is key to improve patient outcome but remains challenging. Despite extensive research, only few biomarkers have so far proven to be helpful in the diagnosis of sepsis. A novel protein biomarker, the pancreatic stone protein (PSP), is showing great promises. Several lines of evidences suggest that PSP has a higher diagnostic performance for the identification of sepsis than procalcitonin and C-reactive protein, and a strong prognostic value to predict unfavorable outcome at admission to intensive care unit. This review summarizes the current knowledge on the molecular mechanisms of PSP function and the clinical evidences available to highlight the relevance of this protein in the diagnosis and prognosis of sepsis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Que, Yok-Ai

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1752-0371

Publisher:

Future Medicine

Language:

English

Submitter:

Mirella Aeberhard

Date Deposited:

29 Aug 2019 13:00

Last Modified:

23 Oct 2019 15:21

Publisher DOI:

10.2217/bmm-2018-0194

PubMed ID:

30672312

Uncontrolled Keywords:

PSP diagnosis diagnostics infection prognosis sepsis

BORIS DOI:

10.7892/boris.132682

URI:

https://boris.unibe.ch/id/eprint/132682

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