Transaminase-catalyzed continous synthesis of biogenic aldehydes

Contente Martina Letizia, Contente; Paradisi, Francesca (2019). Transaminase-catalyzed continous synthesis of biogenic aldehydes. ChemBioChem, 20(22), pp. 2830-2833. Wiley-VCH 10.1002/cbic.201900356

[img] Text
2019 ChemBioChem.pdf - Accepted Version
Restricted to registered users only until 4 June 2020.
Available under License Publisher holds Copyright.

Download (1MB) | Request a copy
[img] Text
ChemBioChem%20rev.pdf - Accepted Version
Restricted to registered users only until 4 June 2020.
Available under License Publisher holds Copyright.

Download (283kB) | Request a copy

The physiological role of biogenic aldehydes such as DOPAL has been associated with cardiovascular and neurodegenerative disorders. The availability of these substrates is limited and robust synthetic methodologies would greatly facilitate further biological studies. Here we report on transaminase mediated single-step process in continuous mode which leads to excellent product yields (90-95%). Co-immoblization of the PLP cofactor eliminated the need of exogenous addition of this reagent without affecting the longevity of the system, delivering a truly self-sufficient process.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Paradisi, Francesca

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

1439-4227

Publisher:

Wiley-VCH

Funders:

[UNSPECIFIED] Marie Skłodowska-Curie
[UNSPECIFIED] Biotechnology and Biological Sciences Research Council

Language:

English

Submitter:

Francesca Paradisi

Date Deposited:

02 Sep 2019 08:58

Last Modified:

19 Nov 2019 01:31

Publisher DOI:

10.1002/cbic.201900356

BORIS DOI:

10.7892/boris.132726

URI:

https://boris.unibe.ch/id/eprint/132726

Actions (login required)

Edit item Edit item
Provide Feedback