Contente Martina Letizia, Contente; Paradisi, Francesca (2019). Transaminase-catalyzed continous synthesis of biogenic aldehydes. ChemBioChem, 20(22), pp. 2830-2833. Wiley-VCH 10.1002/cbic.201900356
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The physiological role of biogenic aldehydes such as DOPAL has been associated with cardiovascular and neurodegenerative disorders. The availability of these substrates is limited and robust synthetic methodologies would greatly facilitate further biological studies. Here we report on transaminase mediated single-step process in continuous mode which leads to excellent product yields (90-95%). Co-immoblization of the PLP cofactor eliminated the need of exogenous addition of this reagent without affecting the longevity of the system, delivering a truly self-sufficient process.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP) |
UniBE Contributor: |
Paradisi, Francesca |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 540 Chemistry |
ISSN: |
1439-4227 |
Publisher: |
Wiley-VCH |
Funders: |
[UNSPECIFIED] Marie Skłodowska-Curie ; [UNSPECIFIED] Biotechnology and Biological Sciences Research Council |
Language: |
English |
Submitter: |
Francesca Paradisi |
Date Deposited: |
02 Sep 2019 08:58 |
Last Modified: |
05 Dec 2022 15:30 |
Publisher DOI: |
10.1002/cbic.201900356 |
BORIS DOI: |
10.7892/boris.132726 |
URI: |
https://boris.unibe.ch/id/eprint/132726 |
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