Liver MRI susceptibility-weighted imaging (SWI) compared to T2* mapping in the presence of steatosis and fibrosis.

Obmann, Verena Carola; Marx, Christina Lynn; Berzigotti, Annalisa; Mertineit, Nando; Hrycyk, Joris; Gräni, Christoph; Ebner, Lukas; Ith, Michael; Heverhagen, Johannes; Christe, Andreas; Huber, Adrian Thomas (2019). Liver MRI susceptibility-weighted imaging (SWI) compared to T2* mapping in the presence of steatosis and fibrosis. European journal of radiology, 118, pp. 66-74. Elsevier 10.1016/j.ejrad.2019.07.001

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To show that both susceptibility-weighted imaging (SWI) and T2*-mapping are dependent on liver steatosis, which should be taken into account when using these parameters to grade liver fibrosis and cirrhosis.


In this prospective study, a total of 174 patients without focal liver disease underwent multiparametric MRI at 3 T including SWI, T1- and T2* mapping, proton density fat fraction (PDFF) quantification and MR elastography. SWI, T2* and T1 were measured in the liver (4 locations), as well as in paraspinal muscles, to calculate the liver-to-muscle ratio (LMR). Liver and LMR values were compared among patients with different steatosis grades (PDFF < 5%, 5-10%, 10-20% and >20%), patients with normal, slightly increased and increased liver stiffness (<2.8 kPa, 2.8-3.5 kPa and >3.5 kPa, respectively). ANOVA with Bonferroni-corrected post hoc tests as well as a multivariate analysis were used to compare values among groups and parameters.


SWI and T2* both differed significantly among groups with different steatosis grades (p < 0.001). However, SWI allowed a better differentiation among liver fibrosis grades (p < 0.001) than did T2* (p = 0.05). SWI LMR (p < 0.001) and T2* LMR (p = 0.036) showed a similar performance in differentiating among liver fibrosis grades.


SWI and T2*-mapping are strongly dependent on the liver steatosis grades. Nevertheless, both parameters are useful predictors for liver fibrosis when using a multiparametric approach.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Obmann, Verena Carola, Marx, Christina Lynn, Berzigotti, Annalisa, Mertineit, Nando, Hrycyk, Joris, Gräni, Christoph, Ebner, Lukas, Ith, Michael, Heverhagen, Johannes, Christe, Andreas, Huber, Adrian Thomas


600 Technology > 610 Medicine & health








Maria de Fatima Henriques Bernardo

Date Deposited:

02 Sep 2019 07:16

Last Modified:

05 Dec 2022 15:30

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Hepatic fibrosis Liver steatosis Magnetic resonance elastography Proton density fat fraction Susceptibility weighted imaging T2* mapping




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