Fusarium onychomycoses in Switzerland-A mycological and histopathological study.

Rammlmair, Anna; Mühlethaler, Konrad; Haneke, Eckart (2019). Fusarium onychomycoses in Switzerland-A mycological and histopathological study. Mycoses, 62(10), pp. 928-931. Wiley-Blackwell 10.1111/myc.12964

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Onychomycoses in temperate climates are most commonly due to dermatophytes, particularly Trichophyton rubrum. Non-dermatophyte nail infections are much less frequent, and their diagnosis requires a careful and repeated search for a potential dermatophyte that may have been overgrown in culture. A series of histological slides of suspected onychomycoses with uncommon fungal morphology prompted us to search for non-dermatophytic moulds causing dermatophytosis-like nail infections. Thirty cases were identified by culture as F solani, F oxysporum, F dimerum or F spp, and two more were only diagnosed histopathologically. None of these patients was immunocompromised. Treatment was mostly unsuccessful with terbinafine whereas itraconazole showed a moderately better treatment result; in all cases, a topical ciclopirox nail varnish in a hydroxychitosan base was added.

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