The tva(A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli.

García-Martín, Ana B.; Schwendener, Sybille; Perreten, Vincent (2019). The tva(A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli. Antimicrobial agents and chemotherapy, 63(9) American Society for Microbiology 10.1128/AAC.00930-19

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The tva(A) gene suspected to confer resistance to pleuromutilins in Brachyspira hyodysenteriae was tested for functionality in Escherichia coli AG100A and Staphylococcus aureus RN4220. Expression of the cloned tva(A) gene conferred decreased susceptibility to pleuromutilin (P) and streptogramin A (SA) antibiotics in E. coli and had a minor effect in S. aureus The finding provides evidence of the direct association of tva(A) with the PSA resistance phenotype.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Veterinary Bacteriology > Molecular Bacterial Epidemiology and Infectiology 05 Veterinary Medicine > Research Foci > Host-Pathogen Interaction 05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP)
Graduate School:	Graduate School for Cellular and Biomedical Sciences (GCB)
UniBE Contributor:	García Martín, Ana Belén, Schwendener, Sybille, Perreten, Vincent
Subjects:	600 Technology > 630 Agriculture 500 Science > 570 Life sciences; biology
ISSN:	0066-4804
Publisher:	American Society for Microbiology
Language:	English
Submitter:	Vincent Perreten
Date Deposited:	20 Sep 2019 11:04
Last Modified:	05 Dec 2022 15:30
Publisher DOI:	10.1128/AAC.00930-19
PubMed ID:	31307989
Uncontrolled Keywords:	ABC-F protein antibiotic resistance gene expression pristinamycin IIA swine dysentery tiamulin valnemulin virginiamycin M1
BORIS DOI:	10.7892/boris.133374
URI:	https://boris.unibe.ch/id/eprint/133374

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The tva(A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli.

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