Identification of two TYRP1 loss-of-function alleles in Valais Red sheep.

Paris, Julia Maria; Letko, Anna; Häfliger, Irene Monika; Ammann, P; Flury, C; Drögemüller, Cord (2019). Identification of two TYRP1 loss-of-function alleles in Valais Red sheep. Animal genetics, 50(6), pp. 778-782. Wiley 10.1111/age.12863

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The Valais Red sheep breed is a local breed of the Swiss canton Valais. Although the breed is characterised by its brown colour, black animals occasionally occur and the objective of this study was to identify the causative genetic variants responsible for the obvious difference. A GWAS using high-density SNP data to compare 51 brown and 38 black sheep showed a strong signal on chromosome 2 at the TYRP1 locus. Haplotype analyses revealed three different brown-associated alleles. The WGS of three sheep revealed four protein-changing variants within the TYRP1 gene. Three of these variants were associated with the recessively inherited brown coat colour. This includes the known missense variant TYRP1:c.869G>T designated as bSoay and two novel loss-of-function variants. We propose to designate the frame-shift variant TYRP1:c.86_87delGA as bVS1 and the nonsense variant TYRP1:c.1066C>T as bVS2 . Interestingly, the bVS1 allele occurs only in local breeds of Switzerland whereas the bVS2 allele seems to be more widespread across Europe.

Item Type:

Journal Article (Original Article)


05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics

UniBE Contributor:

Paris, Julia Maria, Letko, Anna, Häfliger, Irene Monika, Drögemüller, Cord


500 Science > 590 Animals (Zoology)
600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health








Cord Drögemüller

Date Deposited:

04 Oct 2019 15:43

Last Modified:

05 Dec 2022 15:31

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Ovis aries coat colour heterogeneity melanocyte pigmentation




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