Jandus, Peter; Frias Boligan, Kayluz; Smith, David F; de Graauw, Elisabeth; Grimbacher, Bodo; Jandus, Camilla; Abd El Hafez, Mai Moustafa Ahmed; Despont, Alain; Bovin, Nicolai; Simon, Dagmar; Rieben, Robert; Simon, Hans-Uwe; Cummings, Richard D; von Gunten, Stephan (2019). The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies (PADs). Blood, 134(22), pp. 1941-1950. American Society of Hematology 10.1182/blood.2019001705
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von Gunten_Simon_The architecture of the IgG anti-carbohydrate repertoire.pdf - Accepted Version Available under License Publisher holds Copyright. Download (4MB) | Preview |
Immune system failure in primary antibody deficiencies (PADs) has been linked to recurrent infections, autoimmunity and cancer, yet clinical judgment is often based on the reactivity to a restricted panel of antigens. Previously, we demonstrated that the human repertoire of carbohydrate-specific IgG exhibits modular organization related to glycan epitope structure. The current study compares the glycan-specific IgG repertoires among different PAD entities. Distinct repertoire profiles with extensive qualitative glycan-recognition defects were observed, characterized by the common loss of Gala- and GalNAc-reactivity and disease-specific recognition of microbial, self-antigens and tumor-associated carbohydrate antigens. Antibody repertoire analysis may provide a useful tool to elucidate the dimension and clinical implications of the immune system failure in individual patients.
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