High Rates of Hepatitis B Virus (HBV) Functional Cure Among Human Immunodeficiency Virus-HBV Coinfected Patients on Antiretroviral Therapy in Zambia.

Chihota, Belinda V; Wandeler, Gilles; Chilengi, Roma; Mulenga, Lloyd; Chung, Raymond T; Bhattacharya, Debika; Egger, Matthias; Vinikoor, Michael J (2020). High Rates of Hepatitis B Virus (HBV) Functional Cure Among Human Immunodeficiency Virus-HBV Coinfected Patients on Antiretroviral Therapy in Zambia. The journal of infectious diseases, 221(2), pp. 218-222. Oxford University Press 10.1093/infdis/jiz450

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Among 284 human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfected adults starting tenofovir-based antiretroviral therapy (ART) in Zambia, median baseline CD4+ count was 202 cells/mm3 and 41.6% were hepatitis B e-antigen positive. Within 2 years of therapy, 29 (10.2%) participants experienced HBV functional cure (confirmed loss of hepatitis B surface antigen). In multivariable analysis, baseline CD4 count <350 cells/mm3, female sex, and lower baseline HBV deoxyribonucleic acid were associated with increased odds of functional cure. Immune recovery during HIV-HBV treatment with ART may drive higher rates of functional cure than during HBV monoinfection treatment. Understanding the mechanisms underlying this phenomenon could inform immunomodulatory therapies for HBV cure.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Chihota, Belinda Varaidzo; Wandeler, Gilles and Egger, Matthias

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1537-6613

Publisher:

Oxford University Press

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

20 Nov 2019 13:46

Last Modified:

01 Jan 2020 01:31

Publisher DOI:

10.1093/infdis/jiz450

PubMed ID:

31613956

Uncontrolled Keywords:

Africa HBV functional cure HIV-HBV coinfection antiretroviral therapy outcomes

BORIS DOI:

10.7892/boris.134086

URI:

https://boris.unibe.ch/id/eprint/134086

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