Blood pressure in relation to frailty in older adults: A population-based study.

Anker, Daniela; Santos-Eggimann, Brigitte; Zwahlen, Marcel; Santschi, Valérie; Rodondi, Nicolas; Wolfson, Christina; Chiolero, Arnaud (2019). Blood pressure in relation to frailty in older adults: A population-based study. Journal of clinical hypertension, 21(12), pp. 1895-1904. Wiley-Blackwell 10.1111/jch.13722

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In frail older adults, low blood pressure (BP) might be associated with worse health outcomes and hypertension management in this population is highly debated. Using data from a population-based study of older adults, we assessed the association between frailty and BP. We used data collected between 2014 and 2016 from 3157 participants aged between 67 and 80 years in the Lausanne cohort Lc65+. BP was measured three times at one visit, and frailty status was assessed based on Fried's phenotype model. We analyzed the cross-sectional association between BP and frailty by computing mean systolic and diastolic BP stratified by sex, age, and frailty and by fitting regression models. The average age of the participants was 73.3 (standard deviation [SD]: 4.1) years, and 59.1% were women. 34.1% were pre-frail, and 3.3% were frail. Mean BP was 135.1/76.3 mm Hg (SD 18.5/11.0). Age- and sex-adjusted systolic BP was on average lower by 2.8 mm Hg (95% confidence interval [CI]: 1.4-4.2) and 6.7 mm Hg (95% CI: 3.2-10.3) among pre-frail and frail compared to non-frail participants. Similar differences in mean diastolic BP across frailty status were found. Upon adjustment for antihypertensive treatment, the associations between frailty status and BP did not change substantially. Frail individuals had a substantially lower BP compared with non-frail older adults. Because low BP could be detrimental among frail older patients, our findings raise questions about hypertension management in this population and stress the need for additional evidence.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine
04 Faculty of Medicine > Medical Education > Institute of General Practice and Primary Care (BIHAM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Anker, Daniela, Zwahlen, Marcel, Rodondi, Nicolas, Chiolero, Arnaud


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services






[4] Swiss National Science Foundation




Andrea Flükiger-Flückiger

Date Deposited:

05 Nov 2019 16:36

Last Modified:

05 Dec 2022 15:31

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

epidemiology frailty hypertension in the elderly observational population-based




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