Endogenous multidien rhythm of epilepsy in rats.

Baud, Maxime O.; Ghestem, Antoine; Benoliel, Jean-Jacques; Becker, Christel; Bernard, Christophe (2019). Endogenous multidien rhythm of epilepsy in rats. Experimental neurology, 315, pp. 82-87. Elsevier 10.1016/j.expneurol.2019.02.006

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Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Multidien rhythms were not synchronous across animals or with human intervention suggesting an endogenous generator. In epilepsy, across species, unknown factors modulate seizure timing in cyclical patterns over multiple days.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Baud, Maxime Olivier

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0014-4886

Publisher:

Elsevier

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

26 Nov 2019 14:15

Last Modified:

26 Nov 2019 14:15

Publisher DOI:

10.1016/j.expneurol.2019.02.006

PubMed ID:

30776337

Uncontrolled Keywords:

Chronic EEG Chronobiology Circadian Epilepsy Multidien

BORIS DOI:

10.7892/boris.135206

URI:

https://boris.unibe.ch/id/eprint/135206

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