Baud, Maxime O.; Ghestem, Antoine; Benoliel, Jean-Jacques; Becker, Christel; Bernard, Christophe (2019). Endogenous multidien rhythm of epilepsy in rats. Experimental neurology, 315, pp. 82-87. Elsevier 10.1016/j.expneurol.2019.02.006
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Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal. Here, we analyzed chronic EEG data (>30 days) in male epileptic rats and unraveled not only circadian but also, slower, multidien rhythms of interictal epileptiform activity with periodicity of about 2-3 and 5-7 days. Importantly, seizures were not uniformly distributed over time, but rather clustered at preferential phases of these underlying rhythms, delineating critical circadian times and multidien phase of heightened seizure risk. Multidien rhythms were not synchronous across animals or with human intervention suggesting an endogenous generator. In epilepsy, across species, unknown factors modulate seizure timing in cyclical patterns over multiple days.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology |
UniBE Contributor: |
Baud, Maxime |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0014-4886 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Kottler |
Date Deposited: |
26 Nov 2019 14:15 |
Last Modified: |
02 Mar 2023 23:32 |
Publisher DOI: |
10.1016/j.expneurol.2019.02.006 |
PubMed ID: |
30776337 |
Uncontrolled Keywords: |
Chronic EEG Chronobiology Circadian Epilepsy Multidien |
BORIS DOI: |
10.7892/boris.135206 |
URI: |
https://boris.unibe.ch/id/eprint/135206 |
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