Fluid management in patients undergoing cardiac surgery: effects of an acetate- versus lactate-buffered balanced infusion solution on hemodynamic stability (HEMACETAT).

Pfortmueller, Carmen A.; Faeh, Livia; Müller, Martin; Eberle, Balthasar; Jenni, Hansjörg; Zante, Björn; Prazak, Josef; Englberger, Lars; Takala, Jukka; Jakob, Stephan M. (2019). Fluid management in patients undergoing cardiac surgery: effects of an acetate- versus lactate-buffered balanced infusion solution on hemodynamic stability (HEMACETAT). Critical care, 23(1), p. 159. BioMed Central 10.1186/s13054-019-2423-8

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BACKGROUND Recent evidence suggests that acetate-buffered infusions result in better hemodynamic stabilization than 0.9% saline in patients undergoing major surgery. The choice of buffer in balanced crystalloid solutions may modify their hemodynamic effects. We therefore compared the inopressor requirements of Ringer's acetate and lactate for perioperative fluid management in patients undergoing cardiac surgery. METHODS Using a randomized controlled double-blind design, we compared Ringer's acetate (RA) to Ringer's lactate (RL) with respect to the average rate of inopressor administered until postoperative hemodynamic stabilization was achieved. Secondary outcomes were the cumulative dose of inopressors, the duration of inopressor administration, the total fluid volume administered, and the changes in acid-base homeostasis. Patients undergoing elective valvular cardiac surgery were included. Patients with severe cardiac, renal, or liver disease were excluded from the study. RESULTS Seventy-five patients were randomly allocated to the RA arm, 73 to the RL. The hemodynamic profiles were comparable between the groups. The groups did not differ with respect to the average rate of inopressors (RA 2.1 mcg/kg/h, IQR 0.5-8.1 vs. RL 1.7 mcg/kg/h, IQR 0.7-8.2, p = 0.989). Cumulative doses of inopressors and time on individual and combined inopressors did not differ between the groups. No differences were found in acid-base parameters and their evolution over time. CONCLUSION In this study, hemodynamic profiles of patients receiving Ringer's lactate and Ringer's acetate were comparable, and the evolution of acid-base parameters was similar. These study findings should be evaluated in larger, multi-center studies. TRIAL REGISTRATION Clinicaltrials.gov NCT02895659 . Registered 16 September 2016.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Pfortmüller, Carmen; Müller, Martin; Eberle, Balthasar; Jenni, Hansjoerg; Zante, Björn; Prazák, Josef; Englberger, Lars; Takala, Jukka and Jakob, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1364-8535

Publisher:

BioMed Central

Language:

English

Submitter:

Jsabelle Arni

Date Deposited:

05 Dec 2019 13:02

Last Modified:

16 Dec 2019 16:04

Publisher DOI:

10.1186/s13054-019-2423-8

PubMed ID:

31060591

Uncontrolled Keywords:

Cardiac surgical procedures Crystalloid solutions Fluid therapy Hemodynamics Perioperative period Randomized controlled trial Vasoconstrictor agents

BORIS DOI:

10.7892/boris.136162

URI:

https://boris.unibe.ch/id/eprint/136162

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