Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients.

Ogura, Asako; Tsurumi, Amy; Que, Yok-Ai; Almpani, Marianna; Zheng, Hui; Tompkins, Ronald G; Ryan, Colleen M; Rahme, Laurence G (2019). Associations between clinical characteristics and the development of multiple organ failure after severe burns in adult patients. Burns, 45(8), pp. 1775-1782. Elsevier 10.1016/j.burns.2019.02.014

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To determine the association between potential risk factors and multiple organ failure (MOF) in severe burn adult patients, we performed a secondary analysis of data from the "Inflammation and the Host Response to Injury" database, which included patients from six burn centers in the United States between 2003 and 2009. Three hundred twenty-two adult patients (aged ≥16 years) with severe burns (≥20.0% total body surface area [TBSA]) were included. MOF was defined according to the Denver score. Potential risk factors were analyzed for their association with MOF. Models were built using multivariable logistic regression analysis. Eighty-eight patients (27.3%) developed MOF during the study period. We found that TBSA, age, and inhalation injury were significant risk factors for MOF. This predictive model showed good performance, with the total area under the receiver operating characteristic curve being 0.823. Moreover, among patients who developed MOF, inhalation injury was significantly associated with the development of MOF in the acute phase (within three days of injury) (adjusted odds ratio 3.1; 95% confidence interval 1.1-8.3). TBSA, age, lactate, and Denver score within 24h were associated with the late phase development of MOF. Thus, we have identified key risk factors for the onset of MOF after severe burn injury. Our findings contribute to the understanding of individualized treatment and will potentially allow for efficient allocation of resources and a lower threshold for admission to an intensive care unit, which can prevent the development of MOF and eventually reduce mortality.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Que, Yok-Ai


600 Technology > 610 Medicine & health








Isabelle Arni

Date Deposited:

05 Dec 2019 12:52

Last Modified:

05 Dec 2022 15:33

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Adult Denver MOF score Glue Grant Multiple organ failure Risk factors Severe burns




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