Global variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration.

Johnson, Leigh F; Anderegg, Nanina; Zaniewski, Elizabeth; Eaton, Jeffrey W; Rebeiro, Peter F; Carriquiry, Gabriela; Nash, Denis; Yotebieng, Marcel; Ekouevi, Didier K; Holmes, Charles B; Choi, Jun Y; Jiamsakul, Awachana; Bakoyannis, Giorgos; Althoff, Keri N; Sohn, Annette H; Yiannoutsos, Constantin; Egger, Matthias (2019). Global variations in mortality in adults after initiating antiretroviral treatment: an updated analysis of the International epidemiology Databases to Evaluate AIDS cohort collaboration. AIDS, 33 Suppl 3, S283-S294. Lippincott Williams & Wilkins 10.1097/QAD.0000000000002358

[img]
Preview
Text
Johnson AIDS 2019.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (309kB) | Preview

BACKGROUND

UNAIDS models use data from the International epidemiology Databases to Evaluate AIDS (IeDEA) collaboration in setting assumptions about mortality rates after antiretroviral treatment (ART) initiation. This study aims to update these assumptions with new data, to quantify the extent of regional variation in ART mortality and to assess trends in ART mortality.

METHODS

Adult ART patients from Africa, Asia and the Americas were included if they had a known date of ART initiation during 2001-2017 and a baseline CD4 cell count. In cohorts that relied only on passive follow-up (no patient tracing or linkage to vital registration systems), mortality outcomes were imputed in patients lost to follow-up based on a meta-analysis of tracing study data. Poisson regression models were fitted to the mortality data.

RESULTS

464 048 ART patients were included. In multivariable analysis, mortality rates were lowest in Asia and highest in Africa, with no significant differences between African regions. Adjusted mortality rates varied significantly between programmes within regions. Mortality rates in the first 12 months after ART initiation were significantly higher during 2001-2006 than during 2010-2014, although the difference was more substantial in Asia and the Americas [adjusted incidence rate ratio (aIRR) 1.43, 95% CI: 1.22-1.66] than in Africa (aIRR 1.07, 95% CI: 1.04-1.11).

CONCLUSION

There is substantial variation in ART mortality between and within regions, even after controlling for differences in mortality by age, sex, baseline CD4 category and calendar period. ART mortality rates have declined substantially over time, although declines have been slower in Africa.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Anderegg, Nanina Tamar; Zaniewski, Anne Elizabeth and Egger, Matthias

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0269-9370

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

10 Dec 2019 16:18

Last Modified:

10 Mar 2021 03:31

Publisher DOI:

10.1097/QAD.0000000000002358

PubMed ID:

31800405

BORIS DOI:

10.7892/boris.136376

URI:

https://boris.unibe.ch/id/eprint/136376

Actions (login required)

Edit item Edit item
Provide Feedback