Episodes of Fever in Neutropenia in Pediatric Patients With Cancer in Bern, Switzerland, 1993-2012

Zermatten, Maxime G.; Koenig, Christa; von Allmen, Annina; Agyeman, Philipp; Ammann, Roland A. (2019). Episodes of Fever in Neutropenia in Pediatric Patients With Cancer in Bern, Switzerland, 1993-2012. Scientific data, 6(180304), p. 180304. Springer Nature 10.1038/sdata.2018.304

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Fever in neutropenia (FN) is the most frequent potentially life threatening complication of chemotherapy for cancer. Prediction of the risk to develop complications, integrated into clinical decision rules, would allow for risk-stratified treatment of FN. This retrospective, single center cohort study in pediatric patients diagnosed with cancer before 17 years, covered two decades, 1993 to 2012. In total, 703 FN episodes in 291 patients with chemotherapy (maximum per patient, 9) were reported here. Twenty-nine characteristics of FN were collected: 6 were patient- and cancer-related, 8 were characteristics of history, 8 of clinical examination, and 7 laboratory results in peripheral blood, all known at FN diagnosis. In total 28 FN outcomes were assessed: 8 described treatment of FN, 6 described microbiologically defined infections (MDI), 4 clinically defined infections, 4 were additional clinical composite outcomes, and 6 outcomes were related to discharge. These data can mainly be used to study FN characteristics and their association with outcomes over time and between centers, and for derivation and external validation of clinical decision rules.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Haematology/Oncology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Infectiology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Zermatten, Maxime Grégoire; König, Christa; Agyeman, Philipp and Ammann, Roland

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2052-4463

Publisher:

Springer Nature

Language:

English

Submitter:

Philipp Agyeman

Date Deposited:

30 Dec 2019 12:48

Last Modified:

05 Jan 2020 02:43

Publisher DOI:

10.1038/sdata.2018.304

PubMed ID:

30644854

BORIS DOI:

10.7892/boris.136398

URI:

https://boris.unibe.ch/id/eprint/136398

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