Disease Progression and Outcomes of Pregnancies in Women With Eosinophilic Esophagitis.

Schreiner, Philipp; Meissgeier, Silas; Safroneeva, Ekaterina; Greuter, Thomas; Rogler, Gerhard; Schoepfer, Alain; Simon, Dagmar; Simon, Hans-Uwe; Biedermann, Luc; Straumann, Alex (2020). Disease Progression and Outcomes of Pregnancies in Women With Eosinophilic Esophagitis. Clinical gastroenterology and hepatology, 18(11), pp. 2456-2462. Elsevier 10.1016/j.cgh.2019.11.057

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BACKGROUND & AIMS

Eosinophilic esophagitis (EoE) most often affects young patients of reproductive age, yet little is known about its effects during pregnancy. We examined the course of EoE during pregnancy, outcomes of pregnancies, and patient concerns related to pregnancy and EoE.

METHODS

We sent a survey that queried demographic and disease-specific characteristics as well as pregnancy-related topics to all 151 female patients treated at 2 EoE centers in Switzerland. We analyzed cross-sectional survey data.

RESULTS

Of 72 patients that returned the survey, we identified 20 patients that had at least 1 pregnancy and analyzed the data on 34 pregnancies. During pregnancy, improvement of dysphagia was reported in 56% (19/34) of all pregnancies, whereas deterioration was reported in 20% (7/34) of all pregnancies. After delivery, dysphagia returned to the pre-pregnancy level in 68% (13/19) of all pregnancies for patients with improvement of dysphagia and 57% (4/7) of all pregnancies for patients with deterioration of dysphagia during pregnancy. Esophagogastroduodenoscopy during pregnancy was required in less than 10% (3/34) of all pregnancies. Pregnancy-related complications occurred in 12% of pregnancies (4/34). The leading patient-reported concerns were fear of heritability (40% of patients, 8/20) and concerns of that use of medication would harm the fetus (30% of patients, 6/20).

CONCLUSIONS

Pregnancy affects the course of EoE, with improvement of symptoms reported in most patients. Dysphagia returned to the pre-pregnancy level following delivery. EoE has likely no negative effects on outcomes of pregnancies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

UniBE Contributor:

Safroneeva, Ekaterina; Simon, Dagmar and Simon, Hans-Uwe

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

1542-3565

Publisher:

Elsevier

Language:

English

Submitter:

Celine Joray

Date Deposited:

06 Jan 2020 13:47

Last Modified:

03 Mar 2021 01:02

Publisher DOI:

10.1016/j.cgh.2019.11.057

PubMed ID:

31812655

Uncontrolled Keywords:

chronic inflammatory disease esophagus neonate prenatal

BORIS DOI:

10.7892/boris.136955

URI:

https://boris.unibe.ch/id/eprint/136955

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