Deep Learning Versus Classical Regression for Brain Tumor Patient Survival Prediction

Suter, Yannick Raphael; Jungo, Alain; Rebsamen, Michael; Knecht, Urspeter; Herrmann, Evelyn; Wiest, Roland; Reyes, Mauricio (26 January 2019). Deep Learning Versus Classical Regression for Brain Tumor Patient Survival Prediction. Lecture notes in computer science, 11384, pp. 429-440. Cham: Springer 10.1007/978-3-030-11726-9_38

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Deep learning for regression tasks on medical imaging datahas shown promising results. However, compared to other approaches,their power is strongly linked to the dataset size. In this study, we eval-uate 3D-convolutional neural networks (CNNs) and classical regressionmethods with hand-crafted features for survival time regression of pa-tients with high-grade brain tumors. The tested CNNs for regressionshowed promising but unstable results. The best performing deep learn-ing approach reached an accuracy of 51.5% on held-out samples of thetraining set. All tested deep learning experiments were outperformed bya Support Vector Classifier (SVC) using 30 radiomic features. The inves-tigated features included intensity, shape, location and deep features.The submitted method to the BraTS 2018 survival prediction challenge isan ensemble of SVCs, which reached a cross-validated accuracy of 72.2%on the BraTS 2018 training set, 57.1% on the validation set, and 42.9%on the testing set.The results suggest that more training data is necessary for a stable per-formance of a CNN model for direct regression from magnetic resonanceimages, and that non-imaging clinical patient information is crucial alongwith imaging information.

Item Type:

Conference or Workshop Item (Paper)


10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Suter, Yannick Raphael, Jungo, Alain, Herrmann, Evelyn, Wiest, Roland Gerhard Rudi, Reyes, Mauricio


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering








[UNSPECIFIED] Krebsliga Schweiz




Yannick Raphael Suter

Date Deposited:

06 Feb 2020 16:16

Last Modified:

02 Mar 2023 23:32

Publisher DOI:


Additional Information:

Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries / ed. by Alessandro Crimi, Spyridon Bakas, Hugo Kuijf, Farahani Keyvan, Mauricio Reyes, Theo van Walsum




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