Normative data for multiple breath washout outcomes in school-aged Caucasian children.

Anagnostopoulou, Pinelopi; Latzin, Philipp; Jensen, Renee; Stahl, Mirjam; Harper, Alana; Yammine, Sophie; Usemann, Jakob; Foong, Rachel E; Spycher, Ben; Hall, Graham L; Singer, Florian; Stanojevic, Sanja; Mall, Marcus; Ratjen, Felix; Ramsey, Kathryn A (2020). Normative data for multiple breath washout outcomes in school-aged Caucasian children. European respiratory journal, 55(4), p. 1901302. European Respiratory Society 10.1183/13993003.01302-2019

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BACKGROUND The nitrogen multiple breath washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. The aim of this study was to generate reference values for N2MBW outcomes in a cohort of healthy Caucasian school-aged children. METHODS N2MBW data from healthy Caucasian school-age children between 6 and 18 years were collected from four experienced centers. Measurements were performed using an ultrasonic flowmeter (Exhalyzer D, Eco Medics AG, Duernten, Switzerland) and were analyzed with commercial software (Spiroware, 3.2.1, Eco Medics AG). Normative values and upper limits of normal were generated for lung clearance index at 2.5% (LCI2.5%) and at 5% (LCI5%), moment ratios (M1/M0 and M2/M0), and a prediction equation generated for functional residual capacity (FRC). RESULTS Four hundred and eighty five trials from 180 healthy Caucasian children aged from 6 to 18 years were used for analysis. While LCI increased with age, this increase was negligible (0.04 units/year for LCI2.5%) and therefore fixed upper limits of normal were defined for this age group. These limits were 7.91 for LCI2.5%, 5.73 for LCI5%, 1.75 for M1/M0, and 6.15 for M2/M0 respectively. Height and weight were found to be independent predictors of FRC. CONCLUSION We report reference values for N2MBW outcomes measured on a commercially available ultrasonic flowmeter device (Exhalyzer D, Eco Medics AG, Duernten, Switzerland) in healthy school-aged children to allow accurate interpretation of ventilation distribution outcomes and FRC in children with lung disease.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Anagnostopoulou, Pinelopi; Latzin, Philipp; Yammine, Sophie; Usemann, Jakob; Spycher, Ben; Singer, Florian and Ramsey, Kathryn Angela

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0903-1936

Publisher:

European Respiratory Society

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

07 Jan 2020 17:24

Last Modified:

15 Apr 2020 19:32

Publisher DOI:

10.1183/13993003.01302-2019

PubMed ID:

31862765

BORIS DOI:

10.7892/boris.137488

URI:

https://boris.unibe.ch/id/eprint/137488

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