Evaluation of the association between circulating microRNAs and kidney function in coronary angiography patients.

Muendlein, Axel; Geiger, Kathrin; Leiherer, Andreas; Saely, Christoph H; Fraunberger, Peter; Drexel, Heinz (2020). Evaluation of the association between circulating microRNAs and kidney function in coronary angiography patients. American journal of physiology. Renal physiology, 318(2), F315-F321. American Physiological Society 10.1152/ajprenal.00429.2019

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Circulating microRNAs (miRNAs) have been linked to chronic kidney disease. Little is known about the association between circulating miRNAs and kidney function in patients at high cardiovascular risk. We therefore investigated the association between a panel of candidate miRNAs and kidney function, based on estimated glomerular filtration rate (eGFR), in two independent cohorts of patients undergoing coronary angiography. The present study totally included 438 coronary angiography patients, who were divided into a discovery cohort (n=120) and a validation cohort (n=318). A candidate miRNA panel comprising 50 renal miRNAs were selected from the literature and expression levels of circulating miRNAs were determined by real-time PCR. Out of initially tested candidate-miRNAs, 38 were sufficiently detectable in plasma. Their association with kidney function was evaluated in the discovery cohort. Associations of seven out of these miRNAs with eGFR were significant after multiple testing correction via false discovery rate (FDR) estimation. To verify obtained results, miRNAs with significant FDR were further analysed in the validation cohort. MiRNAs miR-106b-5p, miR-16-5p, miR-19b-3p, miR-20a-5p, miR-25-3p, and miR-451a proved to be significantly associated with eGFR also in the validation cohort (all p-values <0.001). Association between identified renal miRNAs and kidney function was confirmed by ANCOVA adjusting for age, gender, type 2 diabetes, hypertension, and albumin-to-creatinine ratio. In conclusion, our study showed that miR-16-5p, miR-19b-3p, miR-20a-5p, miR-25-3p, miR-106b-5p, and miR-451a are significantly linked to kidney function in coronary angiography patients.

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