Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes.

Spyrou, Maria A; Keller, Marcel; Tukhbatova, Rezeda I; Scheib, Christiana L; Nelson, Elizabeth A; Andrades Valtueña, Aida; Neumann, Gunnar U; Walker, Don; Alterauge, Amelie; Carty, Niamh; Cessford, Craig; Fetz, Hermann; Gourvennec, Michaël; Hartle, Robert; Henderson, Michael; von Heyking, Kristin; Inskip, Sarah A; Kacki, Sacha; Key, Felix M; Knox, Elizabeth L; ... (2019). Phylogeography of the second plague pandemic revealed through analysis of historical Yersinia pestis genomes. Nature communications, 10(1), p. 4470. Springer Nature 10.1038/s41467-019-12154-0

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The second plague pandemic, caused by Yersinia pestis, devastated Europe and the nearby regions between the 14th and 18th centuries AD. Here we analyse human remains from ten European archaeological sites spanning this period and reconstruct 34 ancient Y. pestis genomes. Our data support an initial entry of the bacterium through eastern Europe, the absence of genetic diversity during the Black Death, and low within-outbreak diversity thereafter. Analysis of post-Black Death genomes shows the diversification of a Y. pestis lineage into multiple genetically distinct clades that may have given rise to more than one disease reservoir in, or close to, Europe. In addition, we show the loss of a genomic region that includes virulence-related genes in strains associated with late stages of the pandemic. The deletion was also identified in genomes connected with the first plague pandemic (541-750 AD), suggesting a comparable evolutionary trajectory of Y. pestis during both events.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Anthropology

UniBE Contributor:

Alterauge, Amelie Sophie and Lösch, Sandra

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
900 History > 940 History of Europe

ISSN:

2041-1723

Publisher:

Springer Nature

Language:

English

Submitter:

Andrea Stettler

Date Deposited:

03 Jan 2020 14:14

Last Modified:

05 Jan 2020 02:44

Publisher DOI:

10.1038/s41467-019-12154-0

PubMed ID:

31578321

BORIS DOI:

10.7892/boris.137902

URI:

https://boris.unibe.ch/id/eprint/137902

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