Systematic Assessment of Adult Patients' Satisfaction with Various Eosinophilic Esophagitis Therapies.

Safroneeva, Ekaterina; Hafner, David; Kuehni, Claudia E; Zwahlen, Marcel; Trelle, Sven; Biedermann, Luc; Greuter, Thomas; Vavricka, Stephan R; Straumann, Alex; Schoepfer, Alain M (2020). Systematic Assessment of Adult Patients' Satisfaction with Various Eosinophilic Esophagitis Therapies. International archives of allergy and immunology, 181(3), pp. 211-220. Karger 10.1159/000504846

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BACKGROUND AND AIMS

The treatment options for eosinophilic esophagitis (EoE) patients include drugs (proton pump inhibitors [PPIs], swallowed topical corticosteroids [STCs]), elimination diets, and dilation. Given the lack of data, we aimed to assess adult EoE patients' satisfaction with different EoE-specific treatment modalities.

PATIENTS AND METHODS

We evaluated therapy satisfaction recalled over a 12-month period using the validated Treatment Satisfaction Questionnaire for Medication that assesses effectiveness, side effects, convenience, and overall satisfaction. The score for each scale ranges from 0 (dissatisfied) to 100 (satisfied). To evaluate satisfaction with nonpharmacologic therapies, the questionnaire was modified and debriefed into three focus groups. The final questionnaire was sent to 147 patients.

RESULTS

The patient response rate was 74%. In the last 12 months, 24, 75, 19, and 9% were treated with PPIs, STCs, elimination diet, and dilation, respectively. Patients identified the following considerations as important for therapy choice: effect on symptoms (89%), effect on esophageal inflammation (76%), side effects (69%), and ease of use (58%). Patients found STCs to be effective (83 points), convenient (83 points), and experienced no side effects when using this therapy. When using STCs alone (43%), overall patient satisfaction was high (86 points). Patients judged PPIs to be most convenient (89 points), STCs to be a bit less convenient (83 points), and diet to be most inconvenient (46 points) of the three therapies examined.

CONCLUSIONS

Adult EoE patients consider both therapy effect on symptoms and esophageal inflammation as important criteria when choosing EoE therapy and appear to be satisfied with STC use.

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