NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death.

Radulovic, Katarina; Ayata, C Korcan; Mak'Anyengo, Rachel; Lechner, Kristina; Wuggenig, Philipp; Kaya, Berna; Hruz, Petr; Gomez de Agüero, Mercedes; Broz, Petr; Weigmann, Benno; Niess, Jan Hendrik (2019). NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death. Journal of immunology, 203(2), pp. 544-556. American Association of Immunologists 10.4049/jimmunol.1800938

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The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse Nlrp6-deficient T cells following adoptive transfer into Rag2-deficient mice, indicating that Nlrp6 deficiency in CD4+ T cells led to decreased survival.

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