PFM-Like Enzymes Are a Novel Family of Subclass B2 Metallo-β-Lactamases from Pseudomonas synxantha Belonging to the Pseudomonas fluorescens Complex.

Poirel, Laurent; Palmieri, Mattia; Brilhante, Michael; Masseron, Amandine; Perreten, Vincent; Nordmann, Patrice (2020). PFM-Like Enzymes Are a Novel Family of Subclass B2 Metallo-β-Lactamases from Pseudomonas synxantha Belonging to the Pseudomonas fluorescens Complex. Antimicrobial agents and chemotherapy, 64(2) American Society for Microbiology 10.1128/AAC.01700-19

Text Antimicrobial Agents and Chemotherapy-2020-Poirel-e01700-19.full.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

A carbapenem-resistant Pseudomonas synxantha isolate recovered from chicken meat produced the novel carbapenemase PFM-1. That subclass B2 metallo-β-lactamase shared 71% amino acid identity with β-lactamase Sfh-1 from Serratia fonticola The blaPFM-1 gene was chromosomally located and likely acquired. Variants of PFM-1 sharing 90% to 92% amino acid identity were identified in bacterial species belonging to the Pseudomonas fluorescens complex, including Pseudomonas libanensis (PFM-2) and Pseudomonas fluorescens (PFM-3), highlighting that these species constitute reservoirs of PFM-like encoding genes.

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