The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies.

Kutluturk, Isil; Agarwal, Aniruddha; Shulman, Shiri; Vitale, Albert; Parodi, Maurizio B; Conrady, Christoph D; Hurtikova, Katarina; Cunha Souza, Eduardo; Rodriguez, Ever Caso; Chhablani, Jay; Tappeiner, Christoph; Gerding, Heinrich; Zinkernagel, Martin S.; Tucker, William; Munk, Marion R. (2020). The Clinical Characteristics of Unilateral Placoid Pigment Epitheliopathies. (In Press). Ocular immunology and inflammation, pp. 1-8. Taylor & Francis 10.1080/09273948.2019.1705498

Full text not available from this repository. (Request a copy)

Purpose: Placoid-pigment-epitheliopathies like Acute-Posterior-Multifocal-Placoid-Pigment Epitheliopathy (APMPPE) and Relentless-Placoid-Choroidopathy (RPC) usually show bilateral involvement. This retrospective case series describes the clinical features with unilateral disease onset.Methods: 21 patients from 9 tertiary referring institutions were collected and evaluated.Results: Seventeen patients were included: 11 (65%) had unilateral placoid-pigment-epitheliopathy consistent with APMPPE, 6 (35%) with RPC (mean age: 28.82 ± 9.1 years). Mean follow-up time was 45 ± 48 months. Forty-one percent fellow-eyes had initial inflammatory signs including vitreous-cells, vascular-sheathing, and ONH swelling. Thirty-five percent developed chorioretinal lesions during follow-up after 19.5 ± 16.9 months. Initial inflammation in fellow-eye was not associated with fellow-eye involvement (p = .5). However, subfoveal choroidal-thickness (SCT) at baseline was significantly thicker in fellow-eyes who developed chorioretinal lesion compared to fellow-eyes who did not (400 ± 70 µm versus 283 ± 127 µm,p = .047).Conclusion: Unaffected fellow-eyes may have inflammatory signs at initial disease-onset and may develop lesions over time. They should be carefully monitored, particularly if they present with an increased SCT.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Tappeiner, Christoph; Zinkernagel, Martin and Munk, Marion


600 Technology > 610 Medicine & health




Taylor & Francis




Marion Munk

Date Deposited:

16 Mar 2020 14:13

Last Modified:

16 Mar 2020 14:15

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Choroiditis choroidopathy inflammation placoid relentless


Actions (login required)

Edit item Edit item
Provide Feedback